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- W3029978037 abstract "目的 观察总结米托蒽醌(MTZ)联合治疗儿童难治性复发性急性白血病(RRAL)的疗效.方法RRAL 12例,急性淋巴细胞白血病(ALL)9例,急性髓细胞性白血病(AML)3例;ALL用VMLP/Dex方案(长春新碱、米托蒽醌、左旋门冬酰胺酶、泼尼松/地塞米松)2～4周;AML用MAE方案(米托蒽醌、阿糖胞苷、依托泊苷)或大剂量阿糖胞苷+依托泊苷.结果9例ALL,CR 7例,PR 1例,1例未复查;3例AML,CR 2例,NR 1例.总CR率为81.8%(9/11),总有效率90.9%(10/11).用药后骨髓抑制较明显,大部分病例ANE≤0.1×109/L持续1～2周,轻微肝功能损害,未见药物相关的心脏损害.结论MTZ不失为治疗RRAL的有效药物之一,用药后要注意预防和治疗骨髓抑制后出现的各种感染和出血。" @default.
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- W3029978037 date "2006-06-25" @default.
- W3029978037 modified "2023-09-25" @default.
- W3029978037 title "Clinical observation of children patients with recurrent primary refractory acute leukemia treated combination with mitoxantrone" @default.
- W3029978037 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2006.03.017" @default.
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