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- W3029979260 abstract "Objective To evaluate the role of postoperative three-dimensional conformalradiotherapy (3DCRT) in transitional cell carcinoma of the renal pelvis or ureter. Methods Weretrospectively reviewed a series of 103 patients with transitional cell carcinoma of the renal pelvis or ureter.All patients received surgery without distant metastases and had T3 or T4 disease, or grade 3 disease if T2.No patient received chemotherapy. Thirty-seven patients received three-dimensional conformal radiotherapy(3DCRT) following surgery. Sixty-six patients received surgery alone. The local control rates and survivalrates were calculated by Kaplan-Meier method and compared by Logrank test in univariate analysis. Coxregression was used for multivariate analysis. Results The follow-up rates were 89％ and 92％ in surgeryalone and 3DCRT groups. The number of patients who had minimal followed-up time of 5 years were 33 ,37in surgery alone and 3DCRT groups. The 1-,3-, and 5-year local control rates were 89％ vs. 94％ , 74％vs. 90％ , and 72％ vs. 90％ in surgery alone and 3DCRT groups, respectively ( X2 = 3. 90 , P = 0. 048) .The 1-,3-, and 5-year bladder tumor-free survival rates were 87％ vs. 94％ , 60％ vs. 79％ , and 57％ vs.79％ in surgery alone and 3DCRT groups, respectively ( X2 = 4. 50, P = 0. 037) . The 1-,3-, and 5-yearoverall survival rates were 90％ vs. 84％ , 71％ vs. 65％ , and 65％ vs. 62％ in surgery alone and 3DCRTgroups, respectively ( X2 = 0. 32, P = 0. 573 ) . Univariate and multivariate analyses showed that T stage,lymph node metastasis , positive surgical margin were correlated with overall survival rate ( x2 =7. 91 ,64. 69 ,40. 20 and 5. 08 , 17. 23 , 8. 22 , P = 0. 005 ,0. 000 ,0. 000 and 0. 024 , 0. 000 , 0. 004 ) . Conclusions 3DCRTmay improve local control and reduce tumor recurrence in bladder in patients with locally advancedtransitional cell carcinoma of the renal pelvis or ureter. However, 3DCRT does not improve overall survivalin this group of patients.Key words: Renal pelvis ureter neoplasms/surgery; Renal pelvis ureter neoplasms/three-dimensional conformal radiotherapy; Prognosis" @default.
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- W3029979260 date "2012-03-15" @default.
- W3029979260 modified "2023-09-23" @default.
- W3029979260 title "Efficacy of postoperative three-dimensional conformal radiotherapy in transitional cell carcinoma of the renal pelvis or ureter" @default.
- W3029979260 doi "https://doi.org/10.3760/cma.j.issn.1004-4221.2012.02.017" @default.
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