Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030001701> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3030001701 endingPage "99" @default.
- W3030001701 startingPage "95" @default.
- W3030001701 abstract "ObjectiveTo investigate the expression of microRNA (miRNA, miR) -22 (miR-22) in thyroid papillary carcinoma tissue, serum and cell lines, and its relationship with chemotherapy sensitivity.MethodsThe medical records, thyroid papillary carcinoma tissue and serum samples from 21 cases diagnosed thyroid papillary carcinoma were collected. Serum samples from 21 individuals undergoing the physical examination and 21 patients with thyroid nodules were also collected as controls. The expressions of miR-22 in carcinoma tissue, paracarcinoma tissue, serum, normal thyroid cell line and thyroid carcinoma cell line were detected by real-time fluorescent quantitative polymerase chain reaction (real-time qPCR) , and analyzed. Then the target genes and signaling pathways of miR-22 were predicted by bioinformatics software.ResultsThe expression of miR-22 in carcinoma tissue was significantly lower than that in paracancerous tissue, while the expression in serum from thyroid papillary carcinoma patients was significantly higher than that from healthy people and thyroid nodules patients. MiR-22 expression level in carcinoma tissue was negatively correlated with that in carcinoma serum (r=-0.851, P<0.01) . MiR-22 relative expression in carcinoma tissue of T3-T4 stage (0.45±0.08) was significantly lower than that of T1-T2 stage (0.61±0.18) (t=-2.809, P<0.01) ; while the miR-22 relative expression in carcinoma tissue of N- stage (0.64±0.16) was significantly higher than that of N+ stage (0.48±0.10) (t=2.789, P<0.01) . The relative expression of miR-22 in carcinoma serum of T3-T4 stage (12.76±1.60) was significantly higher than that of T1-T2 stage (9.91±2.74) (t=2.806, P<0.01) . The relative expression of miR-22 in patients with high sensitivity to chemotherapy (0.71±0.14) was significantly higher than that in patients with low sensitivity to chemotherapy (0.42±0.13) (t=4.575, P<0.01) . The target genes of miR-22 were SIRT1 and HMGB1 predicted by bioinformatics software, and they took part in many signaling pathways, such as endocytosis, regulation of actin cytoskeleton, MAPK signaling pathway, pathways in cancer and so on.ConclusionsThe expression of miR-22 greatly reduces in carcinoma tissue and cell lines, and is associated with T, N stages and chemotherapy sensitivity. However, the expression increases in serum from thyroid papillary carcinoma patients. MiR-22 takes part in signal pathways and may affect the occurrence and development of thyroid papillary carcinoma through target regulating the expression of SIRT1 and HMGB1.Key words: MicroRNAs; Thyroid papillary carcinoma; Expression quantity; Chemotherapy sensitivity" @default.
- W3030001701 created "2020-06-05" @default.
- W3030001701 creator A5001583563 @default.
- W3030001701 creator A5047660585 @default.
- W3030001701 creator A5052282167 @default.
- W3030001701 creator A5060413216 @default.
- W3030001701 creator A5067368375 @default.
- W3030001701 creator A5085329434 @default.
- W3030001701 date "2017-04-25" @default.
- W3030001701 modified "2023-09-23" @default.
- W3030001701 title "Expression of microRNA-22 in thyroid papillary carcinoma and its relationship with chemotherapy sensitivity" @default.
- W3030001701 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2017.02.005" @default.
- W3030001701 hasPublicationYear "2017" @default.
- W3030001701 type Work @default.
- W3030001701 sameAs 3030001701 @default.
- W3030001701 citedByCount "0" @default.
- W3030001701 crossrefType "journal-article" @default.
- W3030001701 hasAuthorship W3030001701A5001583563 @default.
- W3030001701 hasAuthorship W3030001701A5047660585 @default.
- W3030001701 hasAuthorship W3030001701A5052282167 @default.
- W3030001701 hasAuthorship W3030001701A5060413216 @default.
- W3030001701 hasAuthorship W3030001701A5067368375 @default.
- W3030001701 hasAuthorship W3030001701A5085329434 @default.
- W3030001701 hasConcept C104317684 @default.
- W3030001701 hasConcept C126322002 @default.
- W3030001701 hasConcept C142724271 @default.
- W3030001701 hasConcept C143998085 @default.
- W3030001701 hasConcept C145059251 @default.
- W3030001701 hasConcept C146357865 @default.
- W3030001701 hasConcept C151730666 @default.
- W3030001701 hasConcept C2776694085 @default.
- W3030001701 hasConcept C2777546739 @default.
- W3030001701 hasConcept C2993294228 @default.
- W3030001701 hasConcept C48023723 @default.
- W3030001701 hasConcept C502942594 @default.
- W3030001701 hasConcept C526584372 @default.
- W3030001701 hasConcept C55493867 @default.
- W3030001701 hasConcept C71924100 @default.
- W3030001701 hasConcept C86803240 @default.
- W3030001701 hasConceptScore W3030001701C104317684 @default.
- W3030001701 hasConceptScore W3030001701C126322002 @default.
- W3030001701 hasConceptScore W3030001701C142724271 @default.
- W3030001701 hasConceptScore W3030001701C143998085 @default.
- W3030001701 hasConceptScore W3030001701C145059251 @default.
- W3030001701 hasConceptScore W3030001701C146357865 @default.
- W3030001701 hasConceptScore W3030001701C151730666 @default.
- W3030001701 hasConceptScore W3030001701C2776694085 @default.
- W3030001701 hasConceptScore W3030001701C2777546739 @default.
- W3030001701 hasConceptScore W3030001701C2993294228 @default.
- W3030001701 hasConceptScore W3030001701C48023723 @default.
- W3030001701 hasConceptScore W3030001701C502942594 @default.
- W3030001701 hasConceptScore W3030001701C526584372 @default.
- W3030001701 hasConceptScore W3030001701C55493867 @default.
- W3030001701 hasConceptScore W3030001701C71924100 @default.
- W3030001701 hasConceptScore W3030001701C86803240 @default.
- W3030001701 hasIssue "2" @default.
- W3030001701 hasLocation W30300017011 @default.
- W3030001701 hasOpenAccess W3030001701 @default.
- W3030001701 hasPrimaryLocation W30300017011 @default.
- W3030001701 hasRelatedWork W2117321105 @default.
- W3030001701 hasRelatedWork W2165650493 @default.
- W3030001701 hasRelatedWork W2252971123 @default.
- W3030001701 hasRelatedWork W2353333034 @default.
- W3030001701 hasRelatedWork W2370985582 @default.
- W3030001701 hasRelatedWork W2381538195 @default.
- W3030001701 hasRelatedWork W2589644821 @default.
- W3030001701 hasRelatedWork W2983136758 @default.
- W3030001701 hasRelatedWork W3013068773 @default.
- W3030001701 hasRelatedWork W3024677253 @default.
- W3030001701 hasRelatedWork W3029131444 @default.
- W3030001701 hasRelatedWork W3029611368 @default.
- W3030001701 hasRelatedWork W3031649235 @default.
- W3030001701 hasRelatedWork W3032734303 @default.
- W3030001701 hasRelatedWork W3032792155 @default.
- W3030001701 hasRelatedWork W3092019055 @default.
- W3030001701 hasRelatedWork W3114848845 @default.
- W3030001701 hasRelatedWork W3119246756 @default.
- W3030001701 hasRelatedWork W3144036975 @default.
- W3030001701 hasRelatedWork W2397735182 @default.
- W3030001701 hasVolume "44" @default.
- W3030001701 isParatext "false" @default.
- W3030001701 isRetracted "false" @default.
- W3030001701 magId "3030001701" @default.
- W3030001701 workType "article" @default.