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- W3030009941 abstract "Objective To observe the effects of inhaled budesonide on tumor necrosis factor-α （TNF-α） and platelet-derived growth factor （PDGF） in bronchoalveolar lavage fluid （BALF） of bleomycininduced pulmonary fibrosis rats. Methods Forty-five Wistar female rats were randomly divided into control group（CG）, pulmonary fibrosis model group （MG） and budesonide intervention group （BG）, each group including 15 rats. The model of pulmonary fibrosis was established by a single intratracheal instillation of bleomycin. After 24 hours lboth CG and MG were aerosolized 0.9% NaC1 solution, while BG was aerosolized budesonide. On the 7th, 14th and 28th day after treatment, five rats of each group were sacrificed,respectively, and their lungs were harvested to examine pathological change, hydroxyproline content in lung tissue. Bronchoalveolar lavage was used to detect the concentration of TNF-αand PDGF in BALF. Results The hydroxyproline concentration in lung tissue of BG was lower than that in MG on the 7th, 14th and 28th day（ P 〈0. 05）. The levels of TNF-α and PDGF in BALF of BG were lower than those in MG in early stage（7-14 days） （ P 〈0.05）. Conclusion Inhaled budesonide, especially in early stage. could ameliorate the formation of bleomycin-induced pulmonary fibrosis through inhibiting the release of TNF-α and PDGF.Key words: Pulmonary fibrosis; Budesonide; Hydroxyproline; Tumor necrosis factor-α; Plateletderived growth factor" @default.
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- W3030009941 date "2009-12-20" @default.
- W3030009941 modified "2023-09-27" @default.
- W3030009941 title "Effects of inhaled budesonide on tumor necrosis factor-α and platelet-derived growth factor in bronchoalveolar lavage fluid of pulmonary fibrosis rats" @default.
- W3030009941 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2009.024.004" @default.
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