Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030014506> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3030014506 endingPage "314" @default.
- W3030014506 startingPage "309" @default.
- W3030014506 abstract "ObjectiveTo investigate the expression level and correlation of β-catenin and neural cell adhesion molecule (NCAM) in thyroid carcinoma.MethodsIn this study, the expression levels of NCAM and β-catenin in thyroid carcinoma tissues (n=62) and thyroid adenoma tissues (n=44) collected from patients treated in Wenzhou Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Zhejiang Chinese Medical University from Dec. 2012 to Dec. 2017 were detected by immunohistochemical staining, then its correlation with clinicopathological features was analyzed.ResultsThe positive expression rate of NCAM in thyroid carcinoma tissues was significantly lower than that in thyroid adenoma tissues (12.90% vs 90.91%, t=63.203, P=0.000) . The positive expression rate of β-catenin protein in thyroid carcinoma tissues was significantly higher than that in thyroid adenoma tissues (82.26% vs 6.82%, t=58.608, P=0.000) . NCAM and β-catenin were negatively correlated in thyroid carcinoma tissues (r=-0.220, P=0.024) . The difference of NCAM expression level was not significant among thyroid carcinoma patients with different gender, age, tumor diameter, histological type or pathological stage (t=1.960, 0.054, 3.335, 0.807, 0.218; P=0.162, 0.816, 0.069, 0.848, 0.641) . The expression of NCAM in cancer tissues was significantly different in patients with different lymph node metastasis (t=8.373, P=0.004) . The expression of β-catenin in cancer tissues was not significant in thyroid carcinoma patients with different gender, histological type, tumor diameter, age, lymph node metastasis or pathological stage (t=0.258, 2.307, 0.424, 0.741, 2.570, 0.126; P=0.612, 0.511, 0.515, 0.389, 0.109, 0.722) .ConclusionsIn thyroid carcinoma patients, NCAM is down-regulated, and β-catenin is highly expressed. Moreover, the two indicators are negatively correlated. Additionally, NCAM expression is correlated with lymph node metastasis in thyroid carcinoma patients.Key words: Thyroid carcinoma; β-catenin; NCAM; Expression level; Correlation" @default.
- W3030014506 created "2020-06-05" @default.
- W3030014506 creator A5037016433 @default.
- W3030014506 creator A5048817987 @default.
- W3030014506 creator A5087876606 @default.
- W3030014506 date "2019-08-25" @default.
- W3030014506 modified "2023-09-25" @default.
- W3030014506 title "Expression and correlation of β-Catenin and neural cell adhesion molecule in thyroid carcinoma" @default.
- W3030014506 doi "https://doi.org/10.3760/cma.j.issn.1674-6090.2019.04.011" @default.
- W3030014506 hasPublicationYear "2019" @default.
- W3030014506 type Work @default.
- W3030014506 sameAs 3030014506 @default.
- W3030014506 citedByCount "0" @default.
- W3030014506 crossrefType "journal-article" @default.
- W3030014506 hasAuthorship W3030014506A5037016433 @default.
- W3030014506 hasAuthorship W3030014506A5048817987 @default.
- W3030014506 hasAuthorship W3030014506A5087876606 @default.
- W3030014506 hasConcept C121608353 @default.
- W3030014506 hasConcept C122871604 @default.
- W3030014506 hasConcept C126322002 @default.
- W3030014506 hasConcept C142724271 @default.
- W3030014506 hasConcept C143998085 @default.
- W3030014506 hasConcept C146357865 @default.
- W3030014506 hasConcept C1491633281 @default.
- W3030014506 hasConcept C151730666 @default.
- W3030014506 hasConcept C204232928 @default.
- W3030014506 hasConcept C207886595 @default.
- W3030014506 hasConcept C2777428134 @default.
- W3030014506 hasConcept C2777546739 @default.
- W3030014506 hasConcept C2777802297 @default.
- W3030014506 hasConcept C2779013556 @default.
- W3030014506 hasConcept C2779761222 @default.
- W3030014506 hasConcept C2993294228 @default.
- W3030014506 hasConcept C502942594 @default.
- W3030014506 hasConcept C526584372 @default.
- W3030014506 hasConcept C54355233 @default.
- W3030014506 hasConcept C71924100 @default.
- W3030014506 hasConcept C85789140 @default.
- W3030014506 hasConcept C86803240 @default.
- W3030014506 hasConceptScore W3030014506C121608353 @default.
- W3030014506 hasConceptScore W3030014506C122871604 @default.
- W3030014506 hasConceptScore W3030014506C126322002 @default.
- W3030014506 hasConceptScore W3030014506C142724271 @default.
- W3030014506 hasConceptScore W3030014506C143998085 @default.
- W3030014506 hasConceptScore W3030014506C146357865 @default.
- W3030014506 hasConceptScore W3030014506C1491633281 @default.
- W3030014506 hasConceptScore W3030014506C151730666 @default.
- W3030014506 hasConceptScore W3030014506C204232928 @default.
- W3030014506 hasConceptScore W3030014506C207886595 @default.
- W3030014506 hasConceptScore W3030014506C2777428134 @default.
- W3030014506 hasConceptScore W3030014506C2777546739 @default.
- W3030014506 hasConceptScore W3030014506C2777802297 @default.
- W3030014506 hasConceptScore W3030014506C2779013556 @default.
- W3030014506 hasConceptScore W3030014506C2779761222 @default.
- W3030014506 hasConceptScore W3030014506C2993294228 @default.
- W3030014506 hasConceptScore W3030014506C502942594 @default.
- W3030014506 hasConceptScore W3030014506C526584372 @default.
- W3030014506 hasConceptScore W3030014506C54355233 @default.
- W3030014506 hasConceptScore W3030014506C71924100 @default.
- W3030014506 hasConceptScore W3030014506C85789140 @default.
- W3030014506 hasConceptScore W3030014506C86803240 @default.
- W3030014506 hasIssue "4" @default.
- W3030014506 hasLocation W30300145061 @default.
- W3030014506 hasOpenAccess W3030014506 @default.
- W3030014506 hasPrimaryLocation W30300145061 @default.
- W3030014506 hasRelatedWork W2351696868 @default.
- W3030014506 hasRelatedWork W2359478384 @default.
- W3030014506 hasRelatedWork W2361688476 @default.
- W3030014506 hasRelatedWork W2365434704 @default.
- W3030014506 hasRelatedWork W2369473237 @default.
- W3030014506 hasRelatedWork W2370985582 @default.
- W3030014506 hasRelatedWork W2372639626 @default.
- W3030014506 hasRelatedWork W2372924014 @default.
- W3030014506 hasRelatedWork W2380087647 @default.
- W3030014506 hasRelatedWork W2381538195 @default.
- W3030014506 hasRelatedWork W2388867863 @default.
- W3030014506 hasRelatedWork W2389551003 @default.
- W3030014506 hasRelatedWork W2398904413 @default.
- W3030014506 hasRelatedWork W2415422379 @default.
- W3030014506 hasRelatedWork W3024677253 @default.
- W3030014506 hasRelatedWork W3029345927 @default.
- W3030014506 hasRelatedWork W3029611368 @default.
- W3030014506 hasRelatedWork W3030001701 @default.
- W3030014506 hasRelatedWork W3030122970 @default.
- W3030014506 hasRelatedWork W3032099689 @default.
- W3030014506 hasVolume "13" @default.
- W3030014506 isParatext "false" @default.
- W3030014506 isRetracted "false" @default.
- W3030014506 magId "3030014506" @default.
- W3030014506 workType "article" @default.