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- W3030021828 abstract "BackgroundSepsis means a host create a Specific reaction to infections which leads to life-threatening organ dysfunctions. In case of chronic infection and cancer, T cells occur dysfunction as a result of prolonged antigen exposure, and have a reduced ability to clear pathogens or to eliminate cancer cells. Insights have recently been gained into the role of receptors that negatively regulate T cells which promote T cell dysfunction. Lymphocyte activation gene-3 protein (LAG3, also known as CD223), a inhibitory receptor, come into notice.ObjectiveTo evaluate the therapeutic effects of targeting the LAG3 in the situations such as chronic infection and cancer.ContentThe paper focuses on the Effects on LAG3 on the effector T cell, immune cells, and soluble LAG3, and summarize from clinical trails and discuss the potential mechanism of immune cells.TrendIn the tumor environment, it is very useful in clinic application that LAG3 can negative regulate T cells. LAG3 may also have multiple roles in immune regulation. In the studies of the oncotherapy, how to make using of the immune functions of LAG3 can suppress the proliferation of tumor cells, and take the effect of LAG3 blockage in patients in the future.Key words: Lymphocyte activation gene-3; T cells exhaustion; Co-inhibitory factor" @default.
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- W3030021828 date "2017-03-15" @default.
- W3030021828 modified "2023-09-24" @default.
- W3030021828 title "Research progress on the mechanism of co-inhibition of lymphocyte activation gene-3 in choronic infection and tumor immunity" @default.
- W3030021828 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2017.03.020" @default.
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