Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030023161> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3030023161 endingPage "347" @default.
- W3030023161 startingPage "341" @default.
- W3030023161 abstract "Objective To evaluate the microstructural integrity of white matter (WM) in patients with amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD) using voxel-based analysis (VBA), and investigate the relationship between WM abnormalities and gray matter(GM) atrophy.Methods Thirty-three cases with aMCI, 32 cases with mild AD and 31 normal aging volunteers as control subjects were scanned on a 3.0 T MR system using diffusion tensor imaging (DTI) and three-dimensional spoiled gradient-recalled(3DSPGR) sequences. Fractional anisotropy (FA) maps and morphological images were preprocessed by SPM5 and voxel-based comparisons between the 2 patient groups and the control group were performed by t test. Results Relative to the control group, patients with aMCI showed significantly reduced FA value in bilateral frontal, temporal and left occipital WM, left anterior part of cingulum, left inferior parietal lobule, and the W M adjacent to the triangular part of the right lateral ventricle(k≥20 voxels).In mild AD,significantly reduced FA value was found in bilateral hippocampal,inferior parietal lobular,frontal,temporal,and occipital WM,bilateral corpus callosum,anterior part of cingulums,the WM adjacent to the triaangular part of the bilateral lateral ventricles,left temporal stem,left thalamus,right precuneus(k≥20 voxels).Significantly reduced GM volume was found in left hippocampus,parahippocampal gyrus,lingual gyrus and superior temporal gyrus,bilateral insulae and middle temporal gyri in aMCl group whencompared with control group(k≥50 voxels).In mild AD,significantly reduced GM volume was found in bilateral hippoeampi,parahippocampal gyri,amygdalae,thalami,temporal,parietal,frontal,occipital cortex(k≥50 voxels).The pattern of areas with reduced FA differs;from that of the GM volumetric reduction.No areas with significantlv reduced FA was detected in aMCl compared with mild AD. There was no significant correlation between FA value of WM in patient groups and Mini-Mental State Examination(MMSE)scores.Conclusions Voxel-based MRI DTI analysis of whole brain white matter can objectively reveal widespread white matter abnormalities in early-stage AD.The difierence between WM FA reduction pattern and GM volumetric reduction pattern indicates that the pathological WM changes in earlyslage AD were caused by multiple mechanisms. FA did not vary significantly in patients pr0gressing from aMCI to mild AD and can hardly reflect the severitv of cognitive function damage in these patients.Key words: Cognition disorders; Alzheimer disease; Magnetic resonance imaging" @default.
- W3030023161 created "2020-06-05" @default.
- W3030023161 creator A5010294063 @default.
- W3030023161 creator A5014029292 @default.
- W3030023161 creator A5040805393 @default.
- W3030023161 creator A5076526623 @default.
- W3030023161 date "2011-04-10" @default.
- W3030023161 modified "2023-09-23" @default.
- W3030023161 title "MR diffusion tensor imaging voxel-based analysis of whole brain white matter in patients with amnestic-type mild cognitive impairment and mild Alzheimer disease" @default.
- W3030023161 doi "https://doi.org/10.3760/cma.j.issn.1005-1201.2011.04.005" @default.
- W3030023161 hasPublicationYear "2011" @default.
- W3030023161 type Work @default.
- W3030023161 sameAs 3030023161 @default.
- W3030023161 citedByCount "0" @default.
- W3030023161 crossrefType "journal-article" @default.
- W3030023161 hasAuthorship W3030023161A5010294063 @default.
- W3030023161 hasAuthorship W3030023161A5014029292 @default.
- W3030023161 hasAuthorship W3030023161A5040805393 @default.
- W3030023161 hasAuthorship W3030023161A5076526623 @default.
- W3030023161 hasConcept C105702510 @default.
- W3030023161 hasConcept C118552586 @default.
- W3030023161 hasConcept C126838900 @default.
- W3030023161 hasConcept C143409427 @default.
- W3030023161 hasConcept C149550507 @default.
- W3030023161 hasConcept C2777193593 @default.
- W3030023161 hasConcept C2777944498 @default.
- W3030023161 hasConcept C2778048536 @default.
- W3030023161 hasConcept C2778183499 @default.
- W3030023161 hasConcept C2778186239 @default.
- W3030023161 hasConcept C2779226451 @default.
- W3030023161 hasConcept C2781099131 @default.
- W3030023161 hasConcept C2781192897 @default.
- W3030023161 hasConcept C2781441883 @default.
- W3030023161 hasConcept C54170458 @default.
- W3030023161 hasConcept C71924100 @default.
- W3030023161 hasConcept C89916169 @default.
- W3030023161 hasConceptScore W3030023161C105702510 @default.
- W3030023161 hasConceptScore W3030023161C118552586 @default.
- W3030023161 hasConceptScore W3030023161C126838900 @default.
- W3030023161 hasConceptScore W3030023161C143409427 @default.
- W3030023161 hasConceptScore W3030023161C149550507 @default.
- W3030023161 hasConceptScore W3030023161C2777193593 @default.
- W3030023161 hasConceptScore W3030023161C2777944498 @default.
- W3030023161 hasConceptScore W3030023161C2778048536 @default.
- W3030023161 hasConceptScore W3030023161C2778183499 @default.
- W3030023161 hasConceptScore W3030023161C2778186239 @default.
- W3030023161 hasConceptScore W3030023161C2779226451 @default.
- W3030023161 hasConceptScore W3030023161C2781099131 @default.
- W3030023161 hasConceptScore W3030023161C2781192897 @default.
- W3030023161 hasConceptScore W3030023161C2781441883 @default.
- W3030023161 hasConceptScore W3030023161C54170458 @default.
- W3030023161 hasConceptScore W3030023161C71924100 @default.
- W3030023161 hasConceptScore W3030023161C89916169 @default.
- W3030023161 hasIssue "04" @default.
- W3030023161 hasLocation W30300231611 @default.
- W3030023161 hasOpenAccess W3030023161 @default.
- W3030023161 hasPrimaryLocation W30300231611 @default.
- W3030023161 hasRelatedWork W1436110658 @default.
- W3030023161 hasRelatedWork W1995269864 @default.
- W3030023161 hasRelatedWork W2008808768 @default.
- W3030023161 hasRelatedWork W2012553037 @default.
- W3030023161 hasRelatedWork W2024048084 @default.
- W3030023161 hasRelatedWork W2028991785 @default.
- W3030023161 hasRelatedWork W2029546937 @default.
- W3030023161 hasRelatedWork W2054285206 @default.
- W3030023161 hasRelatedWork W2095322130 @default.
- W3030023161 hasRelatedWork W2215493432 @default.
- W3030023161 hasRelatedWork W2289011538 @default.
- W3030023161 hasRelatedWork W2351931489 @default.
- W3030023161 hasRelatedWork W2352468631 @default.
- W3030023161 hasRelatedWork W2365822611 @default.
- W3030023161 hasRelatedWork W2382114572 @default.
- W3030023161 hasRelatedWork W2384384874 @default.
- W3030023161 hasRelatedWork W2386208486 @default.
- W3030023161 hasRelatedWork W2387995080 @default.
- W3030023161 hasRelatedWork W2474685141 @default.
- W3030023161 hasRelatedWork W3029660693 @default.
- W3030023161 hasVolume "45" @default.
- W3030023161 isParatext "false" @default.
- W3030023161 isRetracted "false" @default.
- W3030023161 magId "3030023161" @default.
- W3030023161 workType "article" @default.