Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030047074> ?p ?o ?g. }
- W3030047074 abstract "Abstract Fungal biofilms cause a major clinical problem with a shrinking armamentarium for treatment. Here, the design and synthesis of voriconazole‐inbuilt zinc 2‐methylimidazolates frameworks (V‐ZIF) is reported. Voriconazole is built in through coordination‐binding between zinc and voriconazole. These metal–organic‐frameworks with inbuilt voriconazole, reduce inadvertent voriconazole‐leakage, yield a zero‐order release kinetics of voriconazole, aid antifungal penetration in Candida albicans biofilms, and prevent Candida aggregation yielding better dispersal. Once accumulated in an acidic C. albicans biofilm, voriconazole dissociates from the metal–organic framework to cause membrane‐damage and killing of inhabiting fungi. Moreover, in a murine model, the V‐ZIFs eradicate open‐wound infections caused by C. albicans better than voriconazole in solution, with negligible side effects to the healthy tissues of major organs. Thus, V‐ZIFs may provide a welcome addition to the antifungal armamentarium currently available for the treatment of fungal biofilms." @default.
- W3030047074 created "2020-06-05" @default.
- W3030047074 creator A5004450349 @default.
- W3030047074 creator A5012138374 @default.
- W3030047074 creator A5021502751 @default.
- W3030047074 creator A5023363049 @default.
- W3030047074 creator A5036422165 @default.
- W3030047074 creator A5038218102 @default.
- W3030047074 creator A5047737595 @default.
- W3030047074 creator A5048970651 @default.
- W3030047074 creator A5058049916 @default.
- W3030047074 creator A5083281746 @default.
- W3030047074 creator A5084915618 @default.
- W3030047074 date "2020-05-28" @default.
- W3030047074 modified "2023-10-14" @default.
- W3030047074 title "Antifungal‐Inbuilt Metal–Organic‐Frameworks Eradicate <i>Candida albicans</i> Biofilms" @default.
- W3030047074 cites W1969179300 @default.
- W3030047074 cites W1980215726 @default.
- W3030047074 cites W1988238185 @default.
- W3030047074 cites W2059631164 @default.
- W3030047074 cites W2079141522 @default.
- W3030047074 cites W2085675301 @default.
- W3030047074 cites W2114368611 @default.
- W3030047074 cites W2124380402 @default.
- W3030047074 cites W2132442646 @default.
- W3030047074 cites W2160708873 @default.
- W3030047074 cites W2161457899 @default.
- W3030047074 cites W2208284809 @default.
- W3030047074 cites W2270881685 @default.
- W3030047074 cites W2309290067 @default.
- W3030047074 cites W2338395605 @default.
- W3030047074 cites W2600535362 @default.
- W3030047074 cites W2614047159 @default.
- W3030047074 cites W2746374204 @default.
- W3030047074 cites W2758396470 @default.
- W3030047074 cites W2759346369 @default.
- W3030047074 cites W2767788055 @default.
- W3030047074 cites W2799518824 @default.
- W3030047074 cites W2800451016 @default.
- W3030047074 cites W2887163385 @default.
- W3030047074 cites W2889392915 @default.
- W3030047074 cites W2901216924 @default.
- W3030047074 cites W2901273961 @default.
- W3030047074 cites W2904585960 @default.
- W3030047074 cites W2908459122 @default.
- W3030047074 cites W2934580730 @default.
- W3030047074 cites W2937563678 @default.
- W3030047074 cites W2946937514 @default.
- W3030047074 cites W2948928172 @default.
- W3030047074 cites W2981383512 @default.
- W3030047074 cites W2984277754 @default.
- W3030047074 cites W3187158005 @default.
- W3030047074 doi "https://doi.org/10.1002/adfm.202000537" @default.
- W3030047074 hasPublicationYear "2020" @default.
- W3030047074 type Work @default.
- W3030047074 sameAs 3030047074 @default.
- W3030047074 citedByCount "36" @default.
- W3030047074 countsByYear W30300470742020 @default.
- W3030047074 countsByYear W30300470742021 @default.
- W3030047074 countsByYear W30300470742022 @default.
- W3030047074 countsByYear W30300470742023 @default.
- W3030047074 crossrefType "journal-article" @default.
- W3030047074 hasAuthorship W3030047074A5004450349 @default.
- W3030047074 hasAuthorship W3030047074A5012138374 @default.
- W3030047074 hasAuthorship W3030047074A5021502751 @default.
- W3030047074 hasAuthorship W3030047074A5023363049 @default.
- W3030047074 hasAuthorship W3030047074A5036422165 @default.
- W3030047074 hasAuthorship W3030047074A5038218102 @default.
- W3030047074 hasAuthorship W3030047074A5047737595 @default.
- W3030047074 hasAuthorship W3030047074A5048970651 @default.
- W3030047074 hasAuthorship W3030047074A5058049916 @default.
- W3030047074 hasAuthorship W3030047074A5083281746 @default.
- W3030047074 hasAuthorship W3030047074A5084915618 @default.
- W3030047074 hasConcept C145081991 @default.
- W3030047074 hasConcept C185592680 @default.
- W3030047074 hasConcept C192562407 @default.
- W3030047074 hasConcept C2779548794 @default.
- W3030047074 hasConcept C2780690907 @default.
- W3030047074 hasConcept C2780917455 @default.
- W3030047074 hasConcept C523546767 @default.
- W3030047074 hasConcept C54355233 @default.
- W3030047074 hasConcept C58123911 @default.
- W3030047074 hasConcept C86803240 @default.
- W3030047074 hasConcept C89423630 @default.
- W3030047074 hasConceptScore W3030047074C145081991 @default.
- W3030047074 hasConceptScore W3030047074C185592680 @default.
- W3030047074 hasConceptScore W3030047074C192562407 @default.
- W3030047074 hasConceptScore W3030047074C2779548794 @default.
- W3030047074 hasConceptScore W3030047074C2780690907 @default.
- W3030047074 hasConceptScore W3030047074C2780917455 @default.
- W3030047074 hasConceptScore W3030047074C523546767 @default.
- W3030047074 hasConceptScore W3030047074C54355233 @default.
- W3030047074 hasConceptScore W3030047074C58123911 @default.
- W3030047074 hasConceptScore W3030047074C86803240 @default.
- W3030047074 hasConceptScore W3030047074C89423630 @default.
- W3030047074 hasFunder F4320321001 @default.
- W3030047074 hasFunder F4320327018 @default.
- W3030047074 hasFunder F4320335777 @default.
- W3030047074 hasIssue "28" @default.
- W3030047074 hasLocation W30300470741 @default.