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- W3030058273 abstract "Objective To investigate the effect and the possible mechanism of apoptosis induction by hedyotic diffusa (HD) on human glioma U87 cells.Methods U87 cells were cultured for 24 and 72 hours in medium which contained hedyotic diffusa with different concentrations,the methyl thiazolyl tetrazolium (MTT) assay was used to detect the survival rate,the apoptosis of the cells was examined by flow cytometry,the change of caspase-3,bcl-2 and bax protein level were measured by Western blotting.Results The cells proliferation was obviously inhibited by hedyotic diffusa and showed a dose dependent manner.The apoptotic rates of the 5,10 ml/L HD groups were (5.22 ±0.29)％,(8.38 ±0.65)％ respectively,all significantly higher than that of the 0 ml/L HD group ( P ＜ 0.05 ).The protein expression of caspase-3 was increased dose-dependently.And the proteins expression of bax was increased and bcl-2-to-bax ratio was reduced dose-dependently.Conclusion Hedytotic diffusa induced glioma U87 cells apoptosis via increase the expression of caspase-3 and bax,decrease the bcl-2-to-bax ratio.Key words: Hedyotic diffusa; Glioma; Cell apoptosis; Mechanism" @default.
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- W3030058273 date "2011-12-08" @default.
- W3030058273 modified "2023-09-23" @default.
- W3030058273 title "Effect of Hedyotic diffusa on U87 glioma cells and its mechanism" @default.
- W3030058273 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2011.12.050" @default.
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