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- W3030075285 abstract "Objective To understand the damaged effect of excess fluoride on kidneys,livers and hearts in experimental rats.Methods The morphologic changes of kidneys,livers and hearts in experimental rats treated with different dose of fluoride for three and five months were observed by microscope.Expression of proliferating cell nuclear antigen (PCNA) was observed in kidney cell by immunohistochemistry.Results The parenchymal cell of kidneys,livers and hearts in experimental rats treated with excess fluoride were swollen and some cells appeared a focus necrosis.The damaged changes of kidneys were more severe and complicated than that in livers and hearts.Especially,many typers of the focus pathological changes appeared as follows in the high excess fluoride groups for five months from the beginning of the experiment:obstruction and dilation of renal tubules,interstitial fibrosis associated with tubular atrophy,mononuclear cell infiltration and proliferate epithelium of PCNA expression;focal necrosis with calcification;granulomatu and infective focus,and so on.Conclusions These results suggested that excess fluoride can injure many viscus organs,the kidneys are damaged heavily and their pathol ogic hanges have various characters." @default.
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- W3030075285 date "2001-03-20" @default.
- W3030075285 modified "2023-09-25" @default.
- W3030075285 title "Pathologic changes of kidneys, livers and hearts in experimental rat s treated with different dose of excess fluoride" @default.
- W3030075285 doi "https://doi.org/10.3760/cma.j.issn.1000-4955.2001.02.008" @default.
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