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• W3030084544 abstract "ObjectiveBy exploring the characteristics of pulmonary ventilation function and airway reactivity in patients with cough variant asthma (CVA), to enhance the cognition of CVA by clinicians.MethodsWe collected 132 patients who were first diagnosed with asthma in the department of respiratory and critical diseases of the First Hospital of Shanxi Medical University from January to November 2017.They were divided into CVA group and typical asthma group according to symptoms, and the former was further divided into extreme mild group, mild group and moderate group based on the methacholine provocative dose causing a 20% fall in FEV1(PD20-FEV1). Then we compared the differences in respiratory velocity in the CVA group, asthma group and each subgroup of the CVA group, and the correlation of age, body mass index (BMI), respiratory velocity and airway stimulation test was also analyzed.ResultsThe incidence rate of small airway dysfunction in the CVA group and the asthma group was 30.9% (21 cases) and 26.6% (17 cases), respectively.There was no significant difference between these groups (χ2=0.3, P>0.05). FEV1/FVC, forced expiratory flow at 25%-75%(FEF25%-75%), forced expiratory flow at 25%(FEF25%), forced expiratory flow at 50%(FEF50%) and peak expiratory flow (PEF) in CVA group were higher than those in asthma group, with statistically significant differences (t=2.239, 2.374, 3.785, 3.088, 2.261, all P<0.05). The overall differences of FEV1/FVC, FEF25%-75%and FEF75% between the extremely mild group, the mild and moderate groups of CVA were statistically significant(F=7.586, 7.403, 7.646, all P<0.05). FEF50% and FEF25% in the extremely mild group were greater than the moderate group (t=3.13, 2.25, all P<0.05), and FEF25% in the mild group was higher than the moderate group(t=2.10, P<0.05). The cumulative dose of methacholine until the resistance of respiratory system began to increase (Dmin) and PD20-FEV1 were positively correlated with FEV1/FVC.The conductance of respiratory system at control and the declining slop of the Grs were negatively correlated with BMI.ConclusionsSmall airway dysfunction can also occur in CVA, but its large and small airway lesions are lighter than typical asthma.The higher the airway reactivity, the worse the index of expiratory flow.Obesity may increase airway sensitivity and reactivity in CVA patients.Key words: Asthma; Respiratory function tests; Bronchial hyperreactivity" @default.
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• W3030084544 date "2019-04-05" @default.
• W3030084544 modified "2023-09-24" @default.
• W3030084544 title "Analysis of pulmonary ventilation function and airway reactivity in patients with cough variant asthma" @default.
• W3030084544 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2019.07.003" @default.
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