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- W3030096115 abstract "目的 评价阿米三嗪-萝巴新治疗轻度血管性痴呆(VD)的疗效和安全性.方法 采用多中心、开放、自身对照试验研究方法,对128例临床诊断为轻度可能的VD患者,给予口服阿米三嗪-萝巴新,每日2片,早晚各1片.分别于服药前及服药后6周和12周,采用简易精神状态(MMSE)量表、AD评估量表-认知部分、Mattis痴呆评价(CDR)量表、日常生活能力(ADL)量表等神经心理分析工具对轻度VD患者的记忆力、注意力、定向力、语言能力、执行能力及生活能力进行评价,并观察有无恶心、头晕等副作用,进行安全性评估.结果 经过3个月阿米三嗪-萝巴新治疗,轻度VD患者的MMSE评分(治疗前16.98,治疗后17.97,P＜0.05),CDR评分(治疗前1.43,治疗后1.21,P＜0.01),ADAS总分(治疗前35.12,治疗后33.08,P＜0.05)以及ADAS因子分中的记忆力和定向力评分、语言能力评分、实践能力评分和ADL评分(治疗前45.55,治疗后43.41,P＜0.01)均有明显改善.阿米三嗪-萝巴新的安全性和依从性良好,在研究期间,3例患者出现皮疹,1例患者因药物作用不明显退出研究,不良事件发生率为2.3%.结论 阿米三嗪-萝巴新可以改善轻度VD的认知功能,提高患者的生活能力,且药物的安全性好。" @default.
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- W3030096115 date "2007-03-23" @default.
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- W3030096115 title "Clinical research on the therapeutic effects and safety of amitrine bismesylate in patients with mild vascular dementia" @default.
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