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- W3030103587 abstract "Human thymic stromal lymphopoietin (TSLP)is an IL-7 like new cytokine. Usually,TSLPmRNA ex-pressed in stroma cells, epithehal cells and mast cells in normal condition. In pathologic state, the expression of TSLPmRNA was upregulated when some proinflammatory factors existed. HTSLP mainly act on dendritic cells in human beings. For one hand, hTSLP-DC can induce naive T cells to differentiate into a specific Th2 cells in periphery tissue which could prime the allergic inflammation. For another hand, hTSLP may also derive the CD4+ CD25- T cells to differentiate into CD4+ CD25+ regulatory T cells (Tregs) in thymus and play important roles in immune tolerance.Key words: hTSLP; DC; Th2; Treg" @default.
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- W3030103587 date "2009-07-05" @default.
- W3030103587 modified "2023-09-25" @default.
- W3030103587 title "Progress in the study of human thymic stromal lymphopoietin" @default.
- W3030103587 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2009.04.021" @default.
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