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- W3030113492 abstract "Modern classification schemes divide cervical adenocarcinomas into human papillomavirus (HPV)-associated and HPV-independent types. The precursor lesions of the former are well known and comprise HPV-associated (usual/endocervical) adenocarcinoma in situ (AIS) and the much less common stratified mucin–producing intraepithelial lesion (SMILE). The precursor lesions of HPV-independent cervical adenocarcinomas are much less well known, although postulated precursors of gastric-type adenocarcinoma include atypical lobular endocervical glandular hyperplasia and gastric-type AIS. In this review, we cover HPV-associated and HPV-independent precursor lesions of cervical adenocarcinomas concentrating on diagnostic criteria (morphology and immunophenotype) and differential diagnosis. We propose a uniform terminology and diagnostic criteria for precursor lesions showing intestinal differentiation with goblet cells because this may be a feature of both HPV-associated and HPV-independent AIS." @default.
- W3030113492 created "2020-06-05" @default.
- W3030113492 creator A5008725360 @default.
- W3030113492 creator A5018811618 @default.
- W3030113492 creator A5023490891 @default.
- W3030113492 date "2020-05-29" @default.
- W3030113492 modified "2023-09-23" @default.
- W3030113492 title "The Evolving Spectrum of Precursor Lesions of Cervical Adenocarcinomas" @default.
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- W3030113492 doi "https://doi.org/10.1097/pap.0000000000000266" @default.
- W3030113492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32482967" @default.
- W3030113492 hasPublicationYear "2020" @default.
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