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- W3030117811 abstract "目的观察谷氨酰胺强化肠内营养对手术后患者机体免疫功能的影响.方法将符合入选标准的 32例消化道手术患者按随机表分别予以肠外营养 (PN组 )、基础型肠内营养 (EN组 )和谷氨酰胺强化肠内营养 (GLN组 ). 3组患者术后第 3天开始至术后第 11天,接受等氮等热卡的营养支持 (92.0 kJ@ kg- 1@ d- 1, 0.2 g N@ kg- 1@ d- 1).观察脏器功能、外周血淋巴细胞亚群、血清免疫球蛋白、血浆谷氨酰胺水平及预后指标.结果 (1)PN组出现一过性肝功能损害的患者较其他 2组为多,但差异无显著性( P=0.11～ 0.24); (2)PN组 CD3+、 CD4+细胞百分比以及 CD4+ /CD8+的比值术后第 11天低于术前水平,且其手术前后的差值明显低于其他两组 (P=0.04, 0.001, 0.006). GLN组术后第 11天与术前 CD25+细胞百分比的差值明显高于 PN组( P=0.01),比较 EN组也有增高趋势( P=0.07); (3) 术后第 11天 PN组患者血浆免疫球蛋白( IgG、 IgM)明显低于术前水平( P=0.04, 0.05),而其他两组已恢复到术前水平; (4)术后第 11天, PN组患者血浆游离谷氨酰胺水平明显低于 EN组和 GLN组( P=0.001); (5)EN组的营养药费用明显低于 PN组( P=0.001).结论 PN组患者有较多一过性肝功能损害.在本研究条件下,肠内营养支持后可减轻免疫功能抑制,谷氨酰胺强化后这种免疫功能得到加强." @default.
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- W3030117811 date "2003-07-25" @default.
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- W3030117811 title "The impact of alanyl-glutamine-enriched enteral nutrition on immune function of postoperative patients" @default.
- W3030117811 doi "https://doi.org/10.3760/cma.j.issn.1671-0274.2003.04.019" @default.
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