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- W3030122970 abstract "The expressions of estrogen receptor (ER) α,ERβ1,and ERβ2 in thyroid carcinoma,thyroid adenoma,and adjacent normal thyroid tissue were determined by RT-PCR and immunohistochemistry,and the relationship of expression levels of three ERs and the main clinical pathologic parameters were evaluated.The result showed that ERα mRNA expression in papillary thyroid carcinoma(PTC) tissues was significantly higher than adjacent normal tissue,while,ERβ2 mRNA expression in PTC tissues was significantly lower than normal tissue ( P<0.05 ).The positive expression of ERβ1 and ERβ2 in the thyroid carcinoma was related with the histological variant of carcinomas; the ERβ2 expressions were related with the lymph node metastasis and TNM staging of the carcinomas.These results suggest that the decreased ERβ2 expression may induce proliferation and carcinogenesis of thyroid follicular epithelial cells as well as progression of the carcinoma,and is a powerful prognostic indicator.Key words: Thyroid neoplasms; Estrogen receptor" @default.
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- W3030122970 date "2011-11-25" @default.
- W3030122970 modified "2023-09-23" @default.
- W3030122970 title "Expressions of estrogen receptor β1 and β2 in human thyroid neoplasms and its clinical implication" @default.
- W3030122970 doi "https://doi.org/10.3760/cma.j.issn.1000-6699.2011.11.016" @default.
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