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- W3030127272 abstract "Circular renin-angiotensin system(RAS) is an important regulator of blood pressure and electrolyte water system. Recently, the study found that the heart, vascular wall, kidney, brain and other organizations also have an independent local RAS, the main regulator of the local tissue growth, differentiation. Local tissue-based RAS has also been described to play a major role in the injury/repair response. The expression of RAS components and the elevation of angiotensin converting enzyme in lung injury suggests the existence of a pulmonary RAS. Angiotensin Ⅱ could mediate, at least in part, the response to lung injury. Activation of a local RAS within the pulmonary circulation and lung parenchyma may influence the extent of lung injury. The presence of c~mmon polymorphisms in RAS genes and their study in relation to specific physiological phenotypes will help both our understanding of the role of RAS in the lung and also the targeting of future therapies.Key words: Renin-angiotensin system; ACE polymorphisms; Lung injury" @default.
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- W3030127272 date "2008-08-05" @default.
- W3030127272 modified "2023-09-23" @default.
- W3030127272 title "Pulmonary renin-angiotensin system" @default.
- W3030127272 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2008.15.010" @default.
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