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- W3030153606 abstract "Objective To investigate the changes of intermedin (IMD) and its receptor system in lung ischemia-reperfusion injury rats and its significance. Methods The rat model of lung ischemiareperfusion was made. Seventy-two healthy male Wistar rats were randomly divided into three groups:surgical control group (C group),ischemia-reperfusion group (IR group) and IMD1-53-pretreated group (D group). At 45 min after ischemia,60 min and 120 min after reperfusion,eight rats in each group were sacrificed,plasma and middle lobe of right lung were collected. The plasma IMD content was determined by radioimmunoassay,the mRNA levels of IMD, calcitonin receptor-like receptor (CL), receptor activitymodifying protein (RAMP)1,2,3 in lung were determined by RT-PCR,and the histopathological study of lung tissue was also performed. Results The plasma IMD content of and the mRNA expression of IMD,CL,RAMP1,2,3 in lung tissue in IR group were lower than those in C group during reperfusion (all P ＜0.05). After pretreamented by IMD1-53, the changes of these indicators induced by ischemia reperfusion were relieved, histopathological examination showed that the degree of lung ischemia-reperfusion injury also significantly improved. Conclusions IMD and its receptor system are involved in the pathogenesis of lung ischemia-reperfusion injury,and may play a protective role.Key words: Lung ischemia-reperfusion injury; Intermedin; Calcitonin receptor-like receptor; Receptor activity-modifying protein; Protection" @default.
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- W3030153606 date "2011-03-20" @default.
- W3030153606 modified "2023-09-24" @default.
- W3030153606 title "Changes of plasma intermedin and its receptor system in lung ischemia-reperfusion injury" @default.
- W3030153606 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2011.006.007" @default.
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