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- W3030158389 abstract "ObjectiveTo evaluate the relationship between plasma substance P(SP)and calcitonin gene-related peptide(CGRP)concentrations and intraoperative cardiovascular events in diabetic patients.MethodsTwenty-two patients of either sex with type 2 diabetes mellitus and 22 non-diabetic patients of either sex, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, aged 50-77 yr, undergoing elective knee arthroplasty under neuraxial anesthesia, served as diabetes mellitus group(group DM)and non-diabetes mellitus group(group NDM), respectively.The patients of either group were further divided into 2 subgroups(n=11 each)according to whether or not the patients had cardiovascular diseases before operation: no cardiovascular disease subgroups(NDM-NCVD subgroup and DM-NCVD subgroup)and cardiovascular disease subgroups(NDM-CVD subgroup and DM-CVD subgroup). The plasma SP and CGRP concentrations were dertermined by enzyme-linked immunosorbent assay at 30 min before operation and at the end of operation.The plasma cardiac troponin I(cTnI)concentrations were measrued by enzyme-linked immunosorbent assay at 30 min before operation and 24 h after operation.The development of intraoperative cardiovascular events was recorded.ResultsCompared with group NDM, the incidence of intraoperative cardiovascular events and plasma cTnI concentrations at each time point were significantly increased, and the plasma concentrations of SP and CGRP were decreased in group DM(P<0.05). Compared with group DM-NCVD, the incidence of intraoperative cardiovascular events and plasma cTnI concentrations at each time point were significantly increased, and the plasma concentrations of SP and CGRP were decreased in group DM-CVD(P<0.05).ConclusionThe development of intraoperative cardiovascular events is related to the decrease in plasma concentrations of SP and CGRP in diabetic patients.Key words: Diabetes mellitus; Substance P; Calcitonin gene-related peptide; Intraoperative complications; Cardiovascular system" @default.
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- W3030158389 date "2017-06-20" @default.
- W3030158389 modified "2023-09-24" @default.
- W3030158389 title "Relationship between plasma substance P and calcitonin gene-related peptide concentrations and intraoperative cardiovascular events in diabetic patients" @default.
- W3030158389 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2017.06.003" @default.
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