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- W3030174770 abstract "目的探讨牛磺酸(Tau)对染铅大鼠学习记忆影响的改善作用.方法40只Wistar大鼠随机均分为5组:空白对照组、铅染毒组(40 mg·kg-1·d-1醋酸铅灌胃4周)、Tau 100 mg组(100mg·kg-1·d-1)、Tau 400 mg组(400 mg·kg-1·d-1)、Tau 800 mg组(800 mg·kg-1·d-1):染铅后继续灌胃4周.第5～8周每周用方位水迷宫试验测试学习记忆能力1次.第8周末处死动物,测定全血铅和脑丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-PX)、一氧化氮合成酶(NOS)、乙酰胆碱酯酶(AChE)等指标水平.结果(1)水迷宫实验中,各Tau治疗组大鼠逃逸时间均少于铅染毒组,其中Tau 800 mg组在第6、7、8周实验、Tau 400 mg组在第6周的实验中,逃逸时间与铅染毒组比较,差异有显著性(P＜0.05).(2)Tau 100、400 mg组大鼠血铅水平分别为(510.90±57.56)、(485.40±98.85)μg/L,与铅染毒组比较,差异有显著性(P＜0.05).(3)Tau 800、400 mg组大鼠脑MDA水平、SOD活力、NOS活力、AChE活力以及Tau 800 mg组GSH含量、GSH-PX活力与铅染毒组比较,差异有显著性(P＜0.05或P＜0.01).结论Tau可改善染铅大鼠的学习记忆能力,对铅染毒大鼠的大脑有一定的保护作用." @default.
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- W3030174770 date "2003-11-20" @default.
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- W3030174770 title "The improvement of taurine in learning and memory ability of rats exposed to lead" @default.
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