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- W3030175130 abstract "Abstract Background Early distinguishing biliary atresia from other causes of infantile cholestasis remains a major challenge. We aimed to develop and validate a scoring system based on bile acid for identification of biliary atresia. Methods In a prospective study, a total of 141 infants with cholestasis were enrolled in two sets (derivation cohort, n = 66; validation cohort, n = 75) from 2014 to 2018. Variables with significant difference between biliary atresia and non-biliary atresia infants were selected in the derivation cohort. Then, a scoring system including those variables was designed and validated. Results Among 66 patients in the derivation cohort, 34 (51.5%) had biliary atresia. A scoring system was proposed with the following variables: glycochenodeoxycholic acid/chenodeoxycholic acid, clay stool, and gamma-glutamyl transferase. The total score ranged from 0 to 41, and a cutoff value of 15 identified biliary atresia with an area under receiver operating characteristic curve of 0.87 (95% confidence interval, 0.77–0.94), sensitivity of 85.3%, and specificity of 81.3% in the derivation cohort; these values were also confirmed in a validation cohort with a sensitivity of 90.0% and specificity of 80.0%. Conclusions The proposed simple scoring system had good diagnostic accuracy for estimating the risk of biliary atresia in infants with cholestasis." @default.
- W3030175130 created "2020-06-05" @default.
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- W3030175130 date "2020-05-27" @default.
- W3030175130 modified "2023-10-10" @default.
- W3030175130 title "Development and validation of bile acid profile-based scoring system for identification of biliary atresia: a prospective study" @default.
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- W3030175130 doi "https://doi.org/10.1186/s12887-020-02169-8" @default.
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