Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030200055> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3030200055 endingPage "469" @default.
- W3030200055 startingPage "467" @default.
- W3030200055 abstract "Objective To investigate the expression of cell inhibitor of apoptosis protein 2(c-IAP2) in pancreatic cancer tissues and its clinical significance,and further study the relationship between c-LAP2 and chemoresistance of pancreatic cancer cells. Methods C-IAP2 expression was examined in 32 cases of pancreatic carcinoma by using immunohistochemistry,and the relationship between c-IAP2 expres-sion and clinicopathology analyzed. A gemcitabine-resistant pancreatic cancer cell line (PANC-1) was ob-tained by gradient increase of concentration. The sensitivity of drug resistance was observed by MTT assay. C-IAP2 expression was detected by immunofluorescence and Western blot in pancreatic cancer cell line. Results C-IAP2 expression was detected in 100.0% (32/32) of pancreatic carcinoma tissues and 44. 4% (8/18) of normal pancreatic tissues, respectively. The expression level of c-IAP2 was higher in pan-creatic carcinoma than in normal pancreatic tissues. Significant correlation was found between the expres-sion of c-IAP2 and tumor differentiation (P<0.05). Three months after being cultured by gemcitabine, the ICS0 of PANC-1 cells was increased from (6.03±0.27) to (41.60±1.14) mg/L (P<0.05). C-IAP2 protein expression levels detected by immunofluorescence and Western blot were significantly in-creased in PANC-1/Gem compared to its parental cell line (P<0.05). Conclusion C-IAP2 may play a role in th the differentiation of pancreatic carcinoma and acquired gemcitabine resistance in pancreatic cancer cell line.Key words: Pancreatic carcinoma; Apoptosis; Chemoresistance" @default.
- W3030200055 created "2020-06-05" @default.
- W3030200055 creator A5053447705 @default.
- W3030200055 creator A5053928221 @default.
- W3030200055 date "2009-04-08" @default.
- W3030200055 modified "2023-09-22" @default.
- W3030200055 title "The relationship between the cell inhibitor of apoptosis protein 2 and chemoresistance in pancreatic cancer" @default.
- W3030200055 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2009.04.024" @default.
- W3030200055 hasPublicationYear "2009" @default.
- W3030200055 type Work @default.
- W3030200055 sameAs 3030200055 @default.
- W3030200055 citedByCount "0" @default.
- W3030200055 crossrefType "journal-article" @default.
- W3030200055 hasAuthorship W3030200055A5053447705 @default.
- W3030200055 hasAuthorship W3030200055A5053928221 @default.
- W3030200055 hasConcept C104317684 @default.
- W3030200055 hasConcept C121608353 @default.
- W3030200055 hasConcept C126322002 @default.
- W3030200055 hasConcept C144369459 @default.
- W3030200055 hasConcept C159654299 @default.
- W3030200055 hasConcept C190283241 @default.
- W3030200055 hasConcept C203014093 @default.
- W3030200055 hasConcept C204232928 @default.
- W3030200055 hasConcept C2776415932 @default.
- W3030200055 hasConcept C2778236600 @default.
- W3030200055 hasConcept C2780210213 @default.
- W3030200055 hasConcept C2780258809 @default.
- W3030200055 hasConcept C2780783641 @default.
- W3030200055 hasConcept C502942594 @default.
- W3030200055 hasConcept C54355233 @default.
- W3030200055 hasConcept C55493867 @default.
- W3030200055 hasConcept C71924100 @default.
- W3030200055 hasConcept C81885089 @default.
- W3030200055 hasConcept C86803240 @default.
- W3030200055 hasConceptScore W3030200055C104317684 @default.
- W3030200055 hasConceptScore W3030200055C121608353 @default.
- W3030200055 hasConceptScore W3030200055C126322002 @default.
- W3030200055 hasConceptScore W3030200055C144369459 @default.
- W3030200055 hasConceptScore W3030200055C159654299 @default.
- W3030200055 hasConceptScore W3030200055C190283241 @default.
- W3030200055 hasConceptScore W3030200055C203014093 @default.
- W3030200055 hasConceptScore W3030200055C204232928 @default.
- W3030200055 hasConceptScore W3030200055C2776415932 @default.
- W3030200055 hasConceptScore W3030200055C2778236600 @default.
- W3030200055 hasConceptScore W3030200055C2780210213 @default.
- W3030200055 hasConceptScore W3030200055C2780258809 @default.
- W3030200055 hasConceptScore W3030200055C2780783641 @default.
- W3030200055 hasConceptScore W3030200055C502942594 @default.
- W3030200055 hasConceptScore W3030200055C54355233 @default.
- W3030200055 hasConceptScore W3030200055C55493867 @default.
- W3030200055 hasConceptScore W3030200055C71924100 @default.
- W3030200055 hasConceptScore W3030200055C81885089 @default.
- W3030200055 hasConceptScore W3030200055C86803240 @default.
- W3030200055 hasIssue "04" @default.
- W3030200055 hasLocation W30302000551 @default.
- W3030200055 hasOpenAccess W3030200055 @default.
- W3030200055 hasPrimaryLocation W30302000551 @default.
- W3030200055 hasRelatedWork W129748989 @default.
- W3030200055 hasRelatedWork W1973773456 @default.
- W3030200055 hasRelatedWork W2050147419 @default.
- W3030200055 hasRelatedWork W2150771385 @default.
- W3030200055 hasRelatedWork W2349550069 @default.
- W3030200055 hasRelatedWork W2353909950 @default.
- W3030200055 hasRelatedWork W2367712401 @default.
- W3030200055 hasRelatedWork W2372555387 @default.
- W3030200055 hasRelatedWork W2373684695 @default.
- W3030200055 hasRelatedWork W2378490905 @default.
- W3030200055 hasRelatedWork W2379868801 @default.
- W3030200055 hasRelatedWork W2380268891 @default.
- W3030200055 hasRelatedWork W2381769557 @default.
- W3030200055 hasRelatedWork W2382620989 @default.
- W3030200055 hasRelatedWork W2388222849 @default.
- W3030200055 hasRelatedWork W2393930441 @default.
- W3030200055 hasRelatedWork W3029043890 @default.
- W3030200055 hasRelatedWork W3029404622 @default.
- W3030200055 hasRelatedWork W3031502786 @default.
- W3030200055 hasRelatedWork W3179512718 @default.
- W3030200055 hasVolume "26" @default.
- W3030200055 isParatext "false" @default.
- W3030200055 isRetracted "false" @default.
- W3030200055 magId "3030200055" @default.
- W3030200055 workType "article" @default.