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- W3030209451 abstract "：Objective To explore therelationship of stromal derived factor 1α(SDF-1α) andCD44variant isoforms (CD44v6) with progress of multiple myeloma (MM). Methods Bone marrowmononuclear cells(MNCs) and bone marrow stromal cells (BMSCs) from 24 cases of MM patients(14 cases of untreated and relapsed and 10 cases of stable MM patients) and 15 cases ofsubjects were investigated as potential SDF-1αand CD44v6 product. The levelof SDF-1α and CD44v6 of the conditionedmedia from MM patients and subjects were analyzed by ELISA. Results The level of SDF-1α and CD44v6 from MNCs in untreated and relapsed MM patients[(7232.41 ± 2644.97) pg/ml and (34.34 ± 13.20) ng/ml] were significantly higher thanstable MM patients [(2315.49 ± 748.29) pg/ml and (15.69 ± 5.28) ng/ml] (t =6.25, t=7.82, P ＜0.05) and 15 subjects [(1149.52 ± 636.06) pg/ml and (4.85 ± 3.62)ng/ml] (t= 4.60, t = 7.61, P＜ 0.05). The level of SDF-1α in stable MM patients was different from healthy subjects (P＜0.05), but the level of CD44v6 in stable MM patients was not different fromcontrols. The level of SDF-1α and CD44v6 in stable MMpatients were significantly higher than health subjects (t = 2.99, t= 4.87, P ＜0.05).The level of SDF-1α was also detected from BMSCsof MM patients. When human MM cell lines U266 were adhered to BMSCs of 9 untreated andrelapsed MM patients,and added rhIL-6 to it, there was significant increase of SDF-1α,compared with BMSCs in subjects and MM patients. The expression level of SDF-lα was correlated with the level of CD44v6 (r =0.51, P =0.03).Conclusion The increase of SDF-1α (may be produced by myelomacells and BMSCs) and CD44v6 (may be produced by myeloma cells) activity is associated withthe progress or pathogenesis of MM, and may be involved with tumor invasion. Thecompletion of these processes in vivo may need participation of myeloma cells, BMSCs,IL-6,SDF-lα and CD44v6." @default.
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- W3030209451 date "2011-04-25" @default.
- W3030209451 modified "2023-09-23" @default.
- W3030209451 title "Study on SDF-1 α and CD44v6 expression in multiple myeloma patients" @default.
- W3030209451 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2011.04.010" @default.
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