Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030209856> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3030209856 endingPage "1180" @default.
- W3030209856 startingPage "1177" @default.
- W3030209856 abstract "BackgroundAlzheimer's disease(AD) is the most common neurodegenerative disorder in the elderly with dementia as featured symptom. The microRNA(miRNA) are a class of non-coding single-stranded RNA composed of 22 nucleotides. They target coding miRNA and cause degradation of the miRNA, inhibiting their translation. Through these procedures, miRNA regulate various physiological functions, including the development and progress of AD.ObjectiveTo review the effects of miRNA on the levels of β-amyloid peptide(Aβ) and tau, neuroinflammation, and synaptic plasticity in AD.ContentAmyloid plaques and neurofibrillary tangles are major pathophysiological hallmarks of AD. Amyloid plaques are formed by the accumulation of Aβ, while neurofibrillary tangles are generated by the excess phosphorylation of tau protein. Some miRNA were discovered to promote or reduce the accumulation of Aβ or production/phosphorylation of tau protein in certain stages of AD. Some miRNA modulate inflammation through TNF-α/NF-κB pathway or IL-1/IL-6 pathway, regulating the development and progress of AD. The levels of miRNA are also demonstrated to involve in the impairment of synaptic plasticity in AD.TrendPathological evidence has demonstrated that miRNA may play important role in the progress of AD, suggesting that some miRNA can be potential biomarkers for stage classifications of AD. Further mechanistic investigations are required to clarify whether miRNA can be therapeutic targets to reverse or curb the deterioration of AD.Key words: MicroRNA; Alzheimer's disease" @default.
- W3030209856 created "2020-06-05" @default.
- W3030209856 creator A5045842655 @default.
- W3030209856 creator A5060950945 @default.
- W3030209856 date "2017-12-15" @default.
- W3030209856 modified "2023-09-27" @default.
- W3030209856 title "Roles of microRNA in the pathophysiology of Alzheimer's disease" @default.
- W3030209856 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2017.12.024" @default.
- W3030209856 hasPublicationYear "2017" @default.
- W3030209856 type Work @default.
- W3030209856 sameAs 3030209856 @default.
- W3030209856 citedByCount "0" @default.
- W3030209856 crossrefType "journal-article" @default.
- W3030209856 hasAuthorship W3030209856A5045842655 @default.
- W3030209856 hasAuthorship W3030209856A5060950945 @default.
- W3030209856 hasConcept C104317684 @default.
- W3030209856 hasConcept C105580179 @default.
- W3030209856 hasConcept C142724271 @default.
- W3030209856 hasConcept C145059251 @default.
- W3030209856 hasConcept C149364088 @default.
- W3030209856 hasConcept C169760540 @default.
- W3030209856 hasConcept C170493617 @default.
- W3030209856 hasConcept C203014093 @default.
- W3030209856 hasConcept C2776914184 @default.
- W3030209856 hasConcept C2779134260 @default.
- W3030209856 hasConcept C2779483572 @default.
- W3030209856 hasConcept C502032728 @default.
- W3030209856 hasConcept C54355233 @default.
- W3030209856 hasConcept C71924100 @default.
- W3030209856 hasConcept C86803240 @default.
- W3030209856 hasConcept C87753298 @default.
- W3030209856 hasConcept C98229152 @default.
- W3030209856 hasConceptScore W3030209856C104317684 @default.
- W3030209856 hasConceptScore W3030209856C105580179 @default.
- W3030209856 hasConceptScore W3030209856C142724271 @default.
- W3030209856 hasConceptScore W3030209856C145059251 @default.
- W3030209856 hasConceptScore W3030209856C149364088 @default.
- W3030209856 hasConceptScore W3030209856C169760540 @default.
- W3030209856 hasConceptScore W3030209856C170493617 @default.
- W3030209856 hasConceptScore W3030209856C203014093 @default.
- W3030209856 hasConceptScore W3030209856C2776914184 @default.
- W3030209856 hasConceptScore W3030209856C2779134260 @default.
- W3030209856 hasConceptScore W3030209856C2779483572 @default.
- W3030209856 hasConceptScore W3030209856C502032728 @default.
- W3030209856 hasConceptScore W3030209856C54355233 @default.
- W3030209856 hasConceptScore W3030209856C71924100 @default.
- W3030209856 hasConceptScore W3030209856C86803240 @default.
- W3030209856 hasConceptScore W3030209856C87753298 @default.
- W3030209856 hasConceptScore W3030209856C98229152 @default.
- W3030209856 hasIssue "12" @default.
- W3030209856 hasLocation W30302098561 @default.
- W3030209856 hasOpenAccess W3030209856 @default.
- W3030209856 hasPrimaryLocation W30302098561 @default.
- W3030209856 hasRelatedWork W1999962781 @default.
- W3030209856 hasRelatedWork W2008978057 @default.
- W3030209856 hasRelatedWork W2021459140 @default.
- W3030209856 hasRelatedWork W2036556087 @default.
- W3030209856 hasRelatedWork W2042330636 @default.
- W3030209856 hasRelatedWork W2545265846 @default.
- W3030209856 hasRelatedWork W2584750431 @default.
- W3030209856 hasRelatedWork W2727423291 @default.
- W3030209856 hasRelatedWork W2737500933 @default.
- W3030209856 hasRelatedWork W2759863376 @default.
- W3030209856 hasRelatedWork W2782487815 @default.
- W3030209856 hasRelatedWork W2782867035 @default.
- W3030209856 hasRelatedWork W2901793375 @default.
- W3030209856 hasRelatedWork W2943536770 @default.
- W3030209856 hasRelatedWork W2951557451 @default.
- W3030209856 hasRelatedWork W3003668627 @default.
- W3030209856 hasRelatedWork W3016444570 @default.
- W3030209856 hasRelatedWork W3081273039 @default.
- W3030209856 hasRelatedWork W3165350110 @default.
- W3030209856 hasRelatedWork W3194258112 @default.
- W3030209856 hasVolume "38" @default.
- W3030209856 isParatext "false" @default.
- W3030209856 isRetracted "false" @default.
- W3030209856 magId "3030209856" @default.
- W3030209856 workType "article" @default.