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- W3030230982 abstract "Objective To study the application of the new biological mesh for herniorrhaphy to alleviate the postoperative inflammation.Methods In 18 New Zealand rabbits,muscle-thickness abdominal wall defect models were established,and randomly assigned to one of three groups:repaired by biomaterials patch (experimental group,EP),repaired by polypropylene mesh group (control group,CP),and repaired without any mesh (negative control group,NP).The number of white blood cells (WBCs),and the liver and renal functions were examined preoperatively and on the postoperative day 3,7,14,21 and 28 in each group.The expression of tumor necrosis factor (TNF)-α and interleukin (IL)-1β was detected simultaneously by using enzyme linked immunosorbent assay (ELISA).All animals were sacrificed after four weeks and the local adhesion was measured.Results There was no abdominal incision infection and death in three groups.The WBCs in each group were increased,and reached the peak at lst-2nd week,and there was significant difference between EP and CP [(10.562 ±0.367) × 109/L vs.(11.785 ±0.452) ×109/L,P < 0.05],but no significant difference between EP and NP.The liver and renal functions among groups had no significant difference after the surgery.The levels of TNF-α and IL-1β in EP and CP were significantly increased as compared with NP (P < 0.05),those in EP after surgery were significantly reduced as compared with CP (P < 0.05),and the difference reached the peak at 2nd week post-operation (P < 0.05).There was lower grade of adherence in EP than in CP after four weeks (5 < 17,P < 0.05).Immunohistochemistry showed biomaterials patch could cause less giant cell reaction.Conclusion This new biological mesh still can cause systemic and local inflammatory response,but much lighter than traditional polypropylene mesh.Its biocompatibility is far superior to that of traditional polypropylene mesh.Key words: Biological mesh ; Incisional hernia; Inflammatory response ; Tumor necrosis factor α; Interleukin 1 β" @default.
- W3030230982 created "2020-06-05" @default.
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- W3030230982 date "2013-06-08" @default.
- W3030230982 modified "2023-09-23" @default.
- W3030230982 title "Application of new biological patch to alleviate the postoperative inflammation" @default.
- W3030230982 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.06.038" @default.
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