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- W3030245890 abstract "ObjectiveTo determine whether dexmedetomidine(Dex) preconditioning could provide cardioprotection against ischemia/reperfusion injury(I/RI) through vagus nerve in rats.MethodsFifty male SD rats, weighing 230-270 g, were randomly divided into five groups(n=10): sham operation (group S), group I/R, unilateral vagotomy(VG)+I/R(group V), Dex+I/R (group D), VG+Dex+I/R(group VD). Dex 1 μg/kg for 10 min and 0.7 μg·kg-1·h-1 for 15 min was infused via the jugular vein. I/R model was established with ligation of left anterior descending coronary artery for 30 min followed by reperfusion for 120 min. Serum levels of IL-6 and TNF-α were measured with ELISA. The mRNA expression of IL-6 and TNF-α in myocardium was assayed with real-time quantitative PCR(qPCR). The area in heart at risk of injury was marked with Evans Blue. The infarct size was stained with 2,3,5-triphenyltetrazolium chloride.ResultsCompared with group I/R, the mRNA and protein levels of IL-6 and TNF-α and the infarct size were significantly decreased in group D(P<0.05). Compared with group D, these parameters were significantly increased in group VD(P<0.05).ConclusionsDex preconditioning protects heart against I/RI in rats by alleviating inflammatory response through intact vagus nerve.Key words: Myocardial ischemia/reperfusion injury; Dexmedetomidine; Vagus nerve; Cholinergic anti-inflammatory pathway" @default.
- W3030245890 created "2020-06-05" @default.
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- W3030245890 date "2017-12-15" @default.
- W3030245890 modified "2023-09-23" @default.
- W3030245890 title "Dexmedetomidine preconditioning attenuates myocardial ischemia/reperfusion injury in rats through intact vagus nerve" @default.
- W3030245890 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2017.12.003" @default.
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