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- W3030251255 abstract "ObjectiveTo explore the significance of self-antibody joint detection for early diagnosis and disease surveillance of children with systemic lupus erythematosus(SLE).MethodsIn October 2012 to July 2016, 90 cases of children with juvenile systemic lupus erythematosus(JLSE)and 74 cases of children with rheumatism were selected for obervation group and disease group respectively.Antibody of double-stranded DNA(dsDNA), anti SSA, anti Sm, anti SSB were detected.AnuA, anti dsDNA and anti Sm were screened out through regression analysis.Analysis respectively for single antibody and joint detection sensitivity and specificity.ResultsThere was significant difference of the sensitivity beteen joint detection of AnuA + anti dsDNA + anti Sm and single antibody, even with anti dsDNA + anti Sm, while there was no the specificity(P>0.05).ConclusionThe combination multiple autoantibodies may improve the sensitivity and efficiency of the diagnosis of JSLE, and it is important for early diagnosis and monitoring of JSLE.Key words: Juvenile systemic lupus erythematosus; Autoantibodies; The joint detection" @default.
- W3030251255 created "2020-06-05" @default.
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- W3030251255 date "2018-11-05" @default.
- W3030251255 modified "2023-09-23" @default.
- W3030251255 title "The clinical significance of the joint detection of autoantibodies in children with juvenile systemic lupus erythematosus" @default.
- W3030251255 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2018.06.008" @default.
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