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- W3030263337 abstract "ObjectiveTo investigate the difference of brain iron deposition among schizophrenia with or without tardive dyskinesia (TD),and healthy volunteers,so as to explore its relationship with pathogenesis of TD.MethodsSusceptibility weighted imaging MRI findings were studied in 14 schizophrenic patients with TD,14 schizophrenic patients without TD,and 14 healthy controls.The corrected phase (CP) of basal ganglia including substantia nigra (SN),caudate nucleus (CN) were measured.The Abnormal Involuntary Movement Scale (AIMS) was used for evaluating the clinical status of TD.ResultsAfter adjusting for age,sex,the mean CP of SN and CN were significantly decreased in TD patients[ (-0.207±0.029),(-0.097±0.021) rad]compared to non-TD patients[ (-0.166±0.031),(-0.075±0.014) rad;d=0.041,0.022; both P=0.001] and healthy subjects[ (-0.142±0.033),(-0.081±0.017) rad;d=0.064,0.015; P=0.000,0.027],while the mean CP of SN was significantly lower in non-TD patients than that in healthy subjects (d=0.024,P=0.043).Decreased mean CP of CN correlated with higher severity score of AIMS in TD patients (rs=-0.508,P=0.025).Logistic regression analysis showed that the decreased CP value in SN (β=-76.869,P=0.026) and CN (β=-185.876,P=0.042),aging (β=0.388,P=0.055) were associated with the onset of TD.ConclusionsThe results indicate the increasein iron accumulation in basal ganglia may be associated with pathogenesis of TD in schizophrenic patients.Key words: Dyskinesia,drug-induced; Schizophrenia; Iron; Magnetic resonance imaging" @default.
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- W3030263337 date "2013-04-05" @default.
- W3030263337 modified "2023-09-22" @default.
- W3030263337 title "A cross-sectional study of brain iron deposition in schizophrenia with tardive dyskinesia" @default.
- W3030263337 doi "https://doi.org/10.3760/cma.j.issn.1006-7884.2013.02.006" @default.
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