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- W3030301940 abstract "Objective To investigate the expression of matrix metalloproteinase (MMP)-1,9 mRNA in lung of rat model of pulmonary hypertension by injection of monocrotaline and their role in pulmonary vascular remodeling.Methods Twenty-four Sprague-Dawley rats were randomized into two groups:monocrotaline group(MCT),control group (Con).The rats in MCT group received a single subcutaneous injection of monocrotaline for 60 mg/kg.Six weeks later,pulmonary tissue were sampled for morphometry,reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization.Results Rats of MCT group had higher T1 and AI than those in the Control group (TI:0.41 ± 0.13 vs 0.13 ± 0.07,P ＜0.05 ; AI:0.64 ± 0.15 vs 0.23 ± 0.11,P ＜ 0.05).The localizations of MMP-1 and MMP-9 in MCT models were endothelial cells and extima fibroblast cells of pulmonary arteries,respectively.The expression of MMP-1 mRNA (0.72± 0.13 vs0.28± 0.01,P＜0.05) and MMP-9 mRNA(0.85 ± 0.15 vs0.39± 0.12,P ＜0.05) in lung was increased in MCT group,compared with that in control group.Conclusion The higher expression level of MMP-1 and MMP-9 may involve in the mechanism of pulmonary vascular remodeling in rat model of pulmonary hypertension by injection of monocrotaline.Key words: Pulmonary artery hypertension; Pulmonary vascular remodeling; Matrix metalloproteinases" @default.
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- W3030301940 date "2013-10-08" @default.
- W3030301940 modified "2023-09-25" @default.
- W3030301940 title "The role of expression of matrix metalloproteinase-1,9 mRNA in rat model of pulmonary hypertension by injection of monocrotaline" @default.
- W3030301940 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.10.036" @default.
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