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- W3030308537 endingPage "588" @default.
- W3030308537 startingPage "586" @default.
- W3030308537 abstract "Alzheimer病(Alzheimer's disease, AD)是老年人常见的神经系统变性病,其临床特点是隐匿起病,病情进行性加重,出现认知障碍和行为异常.病理特点为脑神经细胞外出现β淀粉样肽(Aβ)聚集形成的神经斑或称老年斑、脑神经细胞内tau蛋白异常聚集形成神经原纤维缠结(NFT)、脑皮质神经细胞减少及皮质动脉和小动脉的血管淀粉样变性.AD的病因学和发病机制尚不清楚,但已有许多假说,如Aβ产物过多、tau蛋白的异常磷酸化、过氧化作用、炎症因素、金属与细胞内钙紊乱、遗传因素等[1].近年来因蛋白质折叠障碍造成的异常蛋白质的聚集在神经变性疾病中所起的作用日益受到重视,内质网应激(ERS)与功能障碍也相应受到关注.以下综述AD与内质网应激相关的研究进展。" @default.
- W3030308537 created "2020-06-05" @default.
- W3030308537 creator A5030143683 @default.
- W3030308537 creator A5032644726 @default.
- W3030308537 date "2005-09-23" @default.
- W3030308537 modified "2023-09-25" @default.
- W3030308537 title "内质网应激与Alzheimer病" @default.
- W3030308537 doi "https://doi.org/10.3760/j.issn:1006-7876.2005.09.022" @default.
- W3030308537 hasPublicationYear "2005" @default.
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