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- W3030311874 abstract "Objective To study the elinieopathology characteristics and clinical significance of HIF-1α, VEGF and V EGF-C expression in papillary thyroid carcinoma(FTC) in Rizhao coastal district. Methods A statistic analysis was performed on materials of 253 cases thyroid carcinomas in two Hospitals in Rizhao area. HIF-1α,VEGF and VEGF-C expression were detected by immunohistochenical S-P method in 70 patients of PTC,64 patient s of thyroid adenoma(TA)and 70 patients of nodular goiter(NG). Results The thyroid carci-noma average biopsy ratio was 0. 63%. The total detection rate of thyroid carcinoma changed randomly. The ex-pression of HIF-1α,VEGF and VEGF-C in PTCs was higher than that in TAs and in NGs(P <0.05) and was higher in PTCs with lymph node metastasis than that without metastasis( P <0. 05 ). VEGF and VEGF-C expres-sion had a positive correlation with HIF-1α(P <0. 05). Conclusion The incidence of TC tends to increase af-ter 2004 in Rizhao coastal distric, the change in biopsy ratios may be related with the diagnosis levd markedly improved, the detection rate increased in Thyroid microearcinoma, and ingesting a great deal of iodine and HIF-1α, VEGF and VEGF-C expression significantly increased. These needed further study. Key words: Thyroid carcinoma; Incidence; Hypoxia inducible factor-1α; Vascular endothelial growth factor" @default.
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- W3030311874 date "2009-05-25" @default.
- W3030311874 modified "2023-09-27" @default.
- W3030311874 title "Analysis on the clinicopathology characteristics and clinical significance of HIF-1α,VEGF and VEGF-C expression in thyroid carcinomas in Rizhao coastal district" @default.
- W3030311874 doi "https://doi.org/10.3760/cma.j.issn.1673-8799.2009.05.15" @default.
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