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- W3030315264 abstract "Objective To investigate Helicobacter prlori(Hp) infection and human leukocyte antigen (HLA) DQB1 and DRB1 allelic frequencies among 118 members with and without recurrent abdominal pain in the families.Methods The serum Hp antibody and immunophenotyping was tested and determined by dot immunogold filtration assay and Western blot technique among 118 familial members of 20 familles with recurrent abdominal pain.118 members were divided into two groups:69 members with recurrent abdominal pain.and 49 without such a symptom.PCR-SSP technique was applied to identify HLA-DQB1 and DRB1 allelic frequencies between two groups.Result The Hp sero-positive rate in 118 members was 100％ and the Hp immunophenotyping was 96.6％.The prevalence of Ⅰ and Ⅱ types of Hp were 55.1％ and 41.5％.HLA-DQB1 * 09 and DRB1 * 09 allele frequencies were higher in the members with recurrent abdominal pain than that in the members without recurrent abdominal pain,but there was no significant difference after the allelic Bonferroni correction for comparisons were applied (14％vs 6％,x2 =4.012,P =0.045,Pc ＞0.05;10％vs 5％,x2 =5.636,P =0.018,Pc ＞ 0.05,respectively).Conclusion There is immunogenetic difference between faimial members with and without recurrent abdominal pain infected by Hp.The association between HLA-DQB1 * 09 and DRB1 * 09 allele and the recurrent abdominal pain needs further study.Key words: Helicobacterpylori; Family; HLA-DQB1; HLA-DRB1; Allele" @default.
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- W3030315264 date "2012-01-05" @default.
- W3030315264 modified "2023-09-22" @default.
- W3030315264 title "Helicobacter pylori infection and HLA-DQB1 、DRB1 allelic frequencies among members with and without recurrent abdominal pain in 20 families" @default.
- W3030315264 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2012.01.018" @default.
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