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- W3030317237 abstract "Objective To study the expression of GAP-43 in developingcerebral of hypothyroid rats.Methods The model hypothyroidism was established by pre-treating with Thiamazole and immunocytochemical method.Image analysis was used to observe changes of GAP-43 in cerebral of both normal and hypothyroid neonatal rats.Results The distribution tendency of GAP-43 in parietal neocortex and hippocampal formation was similar in experimental pups as compared to age-matched controls.At 15 d,the grey values of GAP-43 were increased in hypothyroidism (P 0.05) at 30 d.Conclusions Thyroid hormones affects expression of GAP-43 directly or indirectly.By regulating GAP-43,thyroid hormones have an effect on G0 protein signal transduction system and may lead to brain developmental retardation." @default.
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- W3030317237 date "2001-01-20" @default.
- W3030317237 modified "2023-09-25" @default.
- W3030317237 title "Expression of GAP-43 in developing cerebral of hypothyroid rats" @default.
- W3030317237 doi "https://doi.org/10.3760/cma.j.issn.1000-4955.2001.01.009" @default.
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