Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030322012> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3030322012 endingPage "714" @default.
- W3030322012 startingPage "712" @default.
- W3030322012 abstract "Objective To evaluate the effects of propofol on the expression of hippocampal γ-aminobutyric acid (GABAA) and NMDA receptor in a rat model of inflammatory pain (IP).Methods A total of 32 female Sprague-Dawley rats,weighing 180-220 g,were randomly divided into 4 groups (n =8 each):control group (group C),group IP,and different doses of propofol groups (P1,2 groups).IP was induced by injection of formalin.In group C,normal saline and dimethyl sulfoxide (DMSO) 0.1 ml/kg were injected intraperitoneally.In group IP,normal saline and DMSO 0.1 ml/kg were injected intraperitoneally,and 5 min later formalin was injected.In P1,2 groups,propofol 30 and 100 mg/kg were intraperitoneally injected,respectively,and 5 min later formalin was injected.The pain behavior of rats was observed within 1 h after injection of formalin and pain intensity scoring (PIS) value was calculated.The animals were sacrificed at 1 h after injection of formalin and the hippocampi were isolated for determination of GABAA and NMDA receptor expression by immunohistochemisty.Results Compared with group C,PIS value was significantly increased,GABAA and NMDA receptor expression was up-regulated in IP and P1.2 groups.Compared with group IP,PIS value was significantly decreased,GABAA receptor expression was up-regulated,and NMDA receptor expression was down-regulated in P1,2 groups.PIS value was significantly lower,GABAA receptor expression was higher,and NMDA receptor expression was lower in group P2 than in group P1.Conclusion Intraperitoneal propofol can down-regulate NMDA receptor expression in hippocampi of rats with IP,thus inhibiting responses to pain sensitivity; intraperitoneal propofol can up-regulate hippocampal GABAA receptor expression,thus enhancing endogenous mechanism of analgesia.Key words: Propofol; Inflammation; Pain ; Receptors, GABA; Receptors, N-methyl-D-aspartate" @default.
- W3030322012 created "2020-06-05" @default.
- W3030322012 creator A5010237813 @default.
- W3030322012 creator A5060889132 @default.
- W3030322012 creator A5083145041 @default.
- W3030322012 date "2014-06-20" @default.
- W3030322012 modified "2023-09-23" @default.
- W3030322012 title "Effects of propofol on hippocampal GABAA and NMDA receptor expression in a rat model of inflammatory pain" @default.
- W3030322012 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2014.06.018" @default.
- W3030322012 hasPublicationYear "2014" @default.
- W3030322012 type Work @default.
- W3030322012 sameAs 3030322012 @default.
- W3030322012 citedByCount "0" @default.
- W3030322012 crossrefType "journal-article" @default.
- W3030322012 hasAuthorship W3030322012A5010237813 @default.
- W3030322012 hasAuthorship W3030322012A5060889132 @default.
- W3030322012 hasAuthorship W3030322012A5083145041 @default.
- W3030322012 hasConcept C126322002 @default.
- W3030322012 hasConcept C134018914 @default.
- W3030322012 hasConcept C148762608 @default.
- W3030322012 hasConcept C168258287 @default.
- W3030322012 hasConcept C170493617 @default.
- W3030322012 hasConcept C185592680 @default.
- W3030322012 hasConcept C2776277131 @default.
- W3030322012 hasConcept C2777397205 @default.
- W3030322012 hasConcept C2780159080 @default.
- W3030322012 hasConcept C42219234 @default.
- W3030322012 hasConcept C67018056 @default.
- W3030322012 hasConcept C71924100 @default.
- W3030322012 hasConcept C98274493 @default.
- W3030322012 hasConceptScore W3030322012C126322002 @default.
- W3030322012 hasConceptScore W3030322012C134018914 @default.
- W3030322012 hasConceptScore W3030322012C148762608 @default.
- W3030322012 hasConceptScore W3030322012C168258287 @default.
- W3030322012 hasConceptScore W3030322012C170493617 @default.
- W3030322012 hasConceptScore W3030322012C185592680 @default.
- W3030322012 hasConceptScore W3030322012C2776277131 @default.
- W3030322012 hasConceptScore W3030322012C2777397205 @default.
- W3030322012 hasConceptScore W3030322012C2780159080 @default.
- W3030322012 hasConceptScore W3030322012C42219234 @default.
- W3030322012 hasConceptScore W3030322012C67018056 @default.
- W3030322012 hasConceptScore W3030322012C71924100 @default.
- W3030322012 hasConceptScore W3030322012C98274493 @default.
- W3030322012 hasIssue "06" @default.
- W3030322012 hasLocation W30303220121 @default.
- W3030322012 hasOpenAccess W3030322012 @default.
- W3030322012 hasPrimaryLocation W30303220121 @default.
- W3030322012 hasRelatedWork W1977246782 @default.
- W3030322012 hasRelatedWork W2026649160 @default.
- W3030322012 hasRelatedWork W2162310166 @default.
- W3030322012 hasRelatedWork W2352840777 @default.
- W3030322012 hasRelatedWork W2367434319 @default.
- W3030322012 hasRelatedWork W2375310940 @default.
- W3030322012 hasRelatedWork W2379312510 @default.
- W3030322012 hasRelatedWork W2383598038 @default.
- W3030322012 hasRelatedWork W2390022310 @default.
- W3030322012 hasRelatedWork W252298982 @default.
- W3030322012 hasRelatedWork W2587125968 @default.
- W3030322012 hasRelatedWork W2978670284 @default.
- W3030322012 hasRelatedWork W3028686639 @default.
- W3030322012 hasRelatedWork W3028732815 @default.
- W3030322012 hasRelatedWork W3029091733 @default.
- W3030322012 hasRelatedWork W3029113354 @default.
- W3030322012 hasRelatedWork W3029242808 @default.
- W3030322012 hasRelatedWork W3029266426 @default.
- W3030322012 hasRelatedWork W3030436413 @default.
- W3030322012 hasRelatedWork W3031757389 @default.
- W3030322012 hasVolume "34" @default.
- W3030322012 isParatext "false" @default.
- W3030322012 isRetracted "false" @default.
- W3030322012 magId "3030322012" @default.
- W3030322012 workType "article" @default.