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- W3030325815 abstract "Objective To study the effects of Rapamycin and Statin on chronic transplant vasculopathy in rat cardiac allografts.Methods After the establishment of chonic rejection model in rat,the vehicle (control group),Rapamycin,Statin analogs-STA352 and CsA were administered respectively in different groups.The effects of different drugs on the chronic transplant vasculopathy were observed and analyzed by histological methods.Results As compared with animals in control group,graft vascular remodelling of vasculopathy was significantly inhibited in Rapamycin treated rats (P 0.01).In CsA treated animals the vascular remodeling was also significantly inhibited (P 0.01).However there was no significant difference in vasculopathy between STA352 treated animals and control animals.Conclusion Rapamycin can inhibit proliferation of vascular smooth muscle cells and prevent neointimal formation and transplant arteriosclerosis in this model.The present data do not provide strong evidence for inhibition effect by STA352." @default.
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- W3030325815 date "2005-01-01" @default.
- W3030325815 modified "2023-09-25" @default.
- W3030325815 title "The experimental study on the effects of rapamycin and statin on chronic transplant vasculopathy" @default.
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