Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030358049> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3030358049 abstract "Abstract Background Myocardial infarction (MI) affects the expression of a large number of lncRNAs, while the functions of those dysregulated lncRNAs are mostly unclear. Materials and methods Expression of MORT and miR-93 in hearth tissues and plasma of both MI mice and Sham mice and both MI patients and healthy controls was detected by RT-qPCR. Correlations of expression levels of MORT and miR-93 between hear tissues and plasma of MI mice were explored by performing linear regression. Results In the present study we found that MORT expression levels were higher, while expression levels of miR-93 were lower in both plasma and heart tissues of mice MI mice models compared with Sham mice. Plasma levels of MORT and miR-93 were largely consistent with expression levels of MORT and miR-93 in heart tissue of MI mice. MORT expression levels were also higher, while levels of miR-93 were also lower in plasma of MI patients compared with healthy controls. MORT and miR-93 were inversely correlated in MI patients but not in healthy controls. MORT overexpression resulted in inhibited miR-93 expression in cardiomyocytes (AC16 cell line), while miR-93 overexpression did not significantly affect MORT expression. MORT overexpression promoted cardiomyocyte apoptosis, while miR-93 overexpression played and opposite role and attenuated the effects of MORT overexpression. Conclusion Therefore, lncRNA MORT is upregulated in myocardial infarction and promotes the apoptosis of cardiomyocyte by downregulating miR-93." @default.
- W3030358049 created "2020-06-05" @default.
- W3030358049 creator A5003409121 @default.
- W3030358049 creator A5023530787 @default.
- W3030358049 creator A5054061100 @default.
- W3030358049 date "2020-05-25" @default.
- W3030358049 modified "2023-10-12" @default.
- W3030358049 title "LncRNAMORT is upregulated in myocardial infarction and promotes the apoptosis of cardiomyocyte by downregulating miR-93" @default.
- W3030358049 cites W1871610049 @default.
- W3030358049 cites W1960573913 @default.
- W3030358049 cites W1967480655 @default.
- W3030358049 cites W2070887218 @default.
- W3030358049 cites W2100667488 @default.
- W3030358049 cites W2115830594 @default.
- W3030358049 cites W2155698194 @default.
- W3030358049 cites W2198153867 @default.
- W3030358049 cites W2205535611 @default.
- W3030358049 cites W2335029242 @default.
- W3030358049 cites W2340642680 @default.
- W3030358049 cites W2462108616 @default.
- W3030358049 cites W2540331622 @default.
- W3030358049 cites W2542690450 @default.
- W3030358049 cites W2781279551 @default.
- W3030358049 cites W2783395490 @default.
- W3030358049 cites W2788908806 @default.
- W3030358049 cites W2983400233 @default.
- W3030358049 cites W4211143906 @default.
- W3030358049 cites W4211206238 @default.
- W3030358049 cites W58031565 @default.
- W3030358049 doi "https://doi.org/10.1186/s12872-020-01522-0" @default.
- W3030358049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7249308" @default.
- W3030358049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32450811" @default.
- W3030358049 hasPublicationYear "2020" @default.
- W3030358049 type Work @default.
- W3030358049 sameAs 3030358049 @default.
- W3030358049 citedByCount "8" @default.
- W3030358049 countsByYear W30303580492020 @default.
- W3030358049 countsByYear W30303580492021 @default.
- W3030358049 countsByYear W30303580492022 @default.
- W3030358049 countsByYear W30303580492023 @default.
- W3030358049 crossrefType "journal-article" @default.
- W3030358049 hasAuthorship W3030358049A5003409121 @default.
- W3030358049 hasAuthorship W3030358049A5023530787 @default.
- W3030358049 hasAuthorship W3030358049A5054061100 @default.
- W3030358049 hasBestOaLocation W30303580491 @default.
- W3030358049 hasConcept C104317684 @default.
- W3030358049 hasConcept C126322002 @default.
- W3030358049 hasConcept C127561419 @default.
- W3030358049 hasConcept C134018914 @default.
- W3030358049 hasConcept C145059251 @default.
- W3030358049 hasConcept C16685009 @default.
- W3030358049 hasConcept C190283241 @default.
- W3030358049 hasConcept C500558357 @default.
- W3030358049 hasConcept C502942594 @default.
- W3030358049 hasConcept C54355233 @default.
- W3030358049 hasConcept C555175668 @default.
- W3030358049 hasConcept C71924100 @default.
- W3030358049 hasConcept C86803240 @default.
- W3030358049 hasConceptScore W3030358049C104317684 @default.
- W3030358049 hasConceptScore W3030358049C126322002 @default.
- W3030358049 hasConceptScore W3030358049C127561419 @default.
- W3030358049 hasConceptScore W3030358049C134018914 @default.
- W3030358049 hasConceptScore W3030358049C145059251 @default.
- W3030358049 hasConceptScore W3030358049C16685009 @default.
- W3030358049 hasConceptScore W3030358049C190283241 @default.
- W3030358049 hasConceptScore W3030358049C500558357 @default.
- W3030358049 hasConceptScore W3030358049C502942594 @default.
- W3030358049 hasConceptScore W3030358049C54355233 @default.
- W3030358049 hasConceptScore W3030358049C555175668 @default.
- W3030358049 hasConceptScore W3030358049C71924100 @default.
- W3030358049 hasConceptScore W3030358049C86803240 @default.
- W3030358049 hasFunder F4320321001 @default.
- W3030358049 hasIssue "1" @default.
- W3030358049 hasLocation W30303580491 @default.
- W3030358049 hasLocation W30303580492 @default.
- W3030358049 hasLocation W30303580493 @default.
- W3030358049 hasLocation W30303580494 @default.
- W3030358049 hasOpenAccess W3030358049 @default.
- W3030358049 hasPrimaryLocation W30303580491 @default.
- W3030358049 hasRelatedWork W1966504330 @default.
- W3030358049 hasRelatedWork W1979139803 @default.
- W3030358049 hasRelatedWork W2020449916 @default.
- W3030358049 hasRelatedWork W2030889776 @default.
- W3030358049 hasRelatedWork W2037631372 @default.
- W3030358049 hasRelatedWork W2040058909 @default.
- W3030358049 hasRelatedWork W2132898409 @default.
- W3030358049 hasRelatedWork W2367140913 @default.
- W3030358049 hasRelatedWork W2573992804 @default.
- W3030358049 hasRelatedWork W2748952813 @default.
- W3030358049 hasVolume "20" @default.
- W3030358049 isParatext "false" @default.
- W3030358049 isRetracted "false" @default.
- W3030358049 magId "3030358049" @default.
- W3030358049 workType "article" @default.