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- W3030370417 abstract "Objective To study the expression and singnificance of AQP-1 in lung tissue of rats with hypoxic pulmonary hypertension.Methods 60 Wistar male rats which weight rang from 200 g to 280 g were divided into four groups:control group,altitude hypoxia environment 10 d,20 d,30 d group,measured the pulmonary artery pressure of each group and AQP-1 immunohistochemical staining in lung tissue,analysis the expression AQP-1 and the relationship with pulmonary artery pressur.Results The expression intensity of AQP-I and pulmonary artery pressure gradually increased with altitude hypoxia time extension,the expression of AQP-1 and the pulmonary artery pressure slowly increase with time extent.Conclusions AQP-1 and pulmonary artery pressure was positively correlated at the process of altitude hypoxia environment pulmonary hypertension,AQP-1 may play an important role in the development of pulmonary hypertension of hypoxia environment,by regulating the expression of AQP-1 may prevent pulmonary hypertension.Key words: Rats ; Aquaporin-1 ; Hypoxic pulmonary hypertension" @default.
- W3030370417 created "2020-06-05" @default.
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- W3030370417 date "2013-10-05" @default.
- W3030370417 modified "2023-09-23" @default.
- W3030370417 title "Expression and singnificance of AQP-1 in lung tissue of rats with hypoxic pulmonary hypertension" @default.
- W3030370417 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2013.019.007" @default.
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