Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030374906> ?p ?o ?g. }
- W3030374906 endingPage "752" @default.
- W3030374906 startingPage "743" @default.
- W3030374906 abstract "Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer, and thymidine phosphorylase (TP) is a regulator of angiogenesis. To investigate the biological activities of TP in ICC, we established human cholangiocarcinoma RBE cell lines overexpressing TP or silencing TP. Overexpression of TP enhanced viability, suppressed apoptosis and increased tube formation in human umbilical vein endothelial cells, while downregulation of TP reversed these effects. Moreover, an orthotopic xenograft mouse model of ICC was built to further explore TP's function in ICC in vivo. Histological analysis using H&E, TUNEL and Ki67 staining showed that TP promoted tumour growth and inhibited cell apoptosis. Immunostaining for CD31 revealed an elevation in microvessel density in the presence of TP. Besides, upregulation of TP increased the expression of vascular endothelial growth factor, basic fibroblast growth factor, interleukin‐8 and tumour necrosis factor alpha. In contrast, TP knockdown inhibited tumour growth, suppressed microvessel formation and decreased the expression of angiogenesis‐related proteins. Therefore, we suggest that TP promotes angiogenesis and tumour growth in ICC, which can be a potent therapeutic target for ICC treatment." @default.
- W3030374906 created "2020-06-05" @default.
- W3030374906 creator A5004807635 @default.
- W3030374906 creator A5018686969 @default.
- W3030374906 creator A5028454371 @default.
- W3030374906 creator A5035008543 @default.
- W3030374906 creator A5036990231 @default.
- W3030374906 creator A5074040876 @default.
- W3030374906 date "2020-05-31" @default.
- W3030374906 modified "2023-09-30" @default.
- W3030374906 title "Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma" @default.
- W3030374906 cites W1963570372 @default.
- W3030374906 cites W1981486175 @default.
- W3030374906 cites W1985334064 @default.
- W3030374906 cites W1985402482 @default.
- W3030374906 cites W1997066234 @default.
- W3030374906 cites W1997719793 @default.
- W3030374906 cites W1998584720 @default.
- W3030374906 cites W2011995280 @default.
- W3030374906 cites W2012826954 @default.
- W3030374906 cites W2020084657 @default.
- W3030374906 cites W2021948632 @default.
- W3030374906 cites W2033431892 @default.
- W3030374906 cites W2040138472 @default.
- W3030374906 cites W2054435331 @default.
- W3030374906 cites W2055218751 @default.
- W3030374906 cites W2060999907 @default.
- W3030374906 cites W2070287930 @default.
- W3030374906 cites W2076445074 @default.
- W3030374906 cites W2078797029 @default.
- W3030374906 cites W2081143051 @default.
- W3030374906 cites W2121390208 @default.
- W3030374906 cites W2126336984 @default.
- W3030374906 cites W2134027750 @default.
- W3030374906 cites W2159397285 @default.
- W3030374906 cites W2164025875 @default.
- W3030374906 cites W2168202400 @default.
- W3030374906 cites W2214823238 @default.
- W3030374906 cites W2290579175 @default.
- W3030374906 cites W2478316961 @default.
- W3030374906 cites W2597795073 @default.
- W3030374906 cites W2612574275 @default.
- W3030374906 cites W2731227355 @default.
- W3030374906 cites W2738755748 @default.
- W3030374906 cites W2775137578 @default.
- W3030374906 cites W2775501278 @default.
- W3030374906 cites W2802466304 @default.
- W3030374906 cites W2804842145 @default.
- W3030374906 cites W2809643721 @default.
- W3030374906 cites W4211025847 @default.
- W3030374906 cites W658604617 @default.
- W3030374906 doi "https://doi.org/10.1002/cbf.3541" @default.
- W3030374906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32476180" @default.
- W3030374906 hasPublicationYear "2020" @default.
- W3030374906 type Work @default.
- W3030374906 sameAs 3030374906 @default.
- W3030374906 citedByCount "4" @default.
- W3030374906 countsByYear W30303749062021 @default.
- W3030374906 countsByYear W30303749062022 @default.
- W3030374906 countsByYear W30303749062023 @default.
- W3030374906 crossrefType "journal-article" @default.
- W3030374906 hasAuthorship W3030374906A5004807635 @default.
- W3030374906 hasAuthorship W3030374906A5018686969 @default.
- W3030374906 hasAuthorship W3030374906A5028454371 @default.
- W3030374906 hasAuthorship W3030374906A5035008543 @default.
- W3030374906 hasAuthorship W3030374906A5036990231 @default.
- W3030374906 hasAuthorship W3030374906A5074040876 @default.
- W3030374906 hasConcept C104317684 @default.
- W3030374906 hasConcept C121608353 @default.
- W3030374906 hasConcept C127561419 @default.
- W3030374906 hasConcept C167734588 @default.
- W3030374906 hasConcept C170493617 @default.
- W3030374906 hasConcept C185592680 @default.
- W3030374906 hasConcept C202751555 @default.
- W3030374906 hasConcept C2775960820 @default.
- W3030374906 hasConcept C2776735402 @default.
- W3030374906 hasConcept C2777025900 @default.
- W3030374906 hasConcept C2777411675 @default.
- W3030374906 hasConcept C2777587049 @default.
- W3030374906 hasConcept C2777834122 @default.
- W3030374906 hasConcept C2778271429 @default.
- W3030374906 hasConcept C2778939058 @default.
- W3030374906 hasConcept C2780394083 @default.
- W3030374906 hasConcept C502942594 @default.
- W3030374906 hasConcept C54355233 @default.
- W3030374906 hasConcept C55493867 @default.
- W3030374906 hasConcept C62112901 @default.
- W3030374906 hasConcept C86803240 @default.
- W3030374906 hasConceptScore W3030374906C104317684 @default.
- W3030374906 hasConceptScore W3030374906C121608353 @default.
- W3030374906 hasConceptScore W3030374906C127561419 @default.
- W3030374906 hasConceptScore W3030374906C167734588 @default.
- W3030374906 hasConceptScore W3030374906C170493617 @default.
- W3030374906 hasConceptScore W3030374906C185592680 @default.
- W3030374906 hasConceptScore W3030374906C202751555 @default.
- W3030374906 hasConceptScore W3030374906C2775960820 @default.
- W3030374906 hasConceptScore W3030374906C2776735402 @default.
- W3030374906 hasConceptScore W3030374906C2777025900 @default.