FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3030385140> ?p ?o ?g. }

• W3030385140 abstract "Abstract Oryctes rhinoceros nudivirus (OrNV) is a large circular double-stranded DNA virus which has been used as a biological control agent to suppress Coconut Rhinoceros Beetle ( Oryctes rhinoceros ) in Southeast Asia and the Pacific Islands. Recently a new wave of O. rhinoceros incursions in Oceania in previously non-infested areas is thought to be related to the presence of low virulence isolates of OrNV or virus tolerant haplotypes of beetles. In this study, chronically infected O. rhinoceros adults were field collected from the Philippines, Fiji, Papua New Guinea and the Solomon Islands. We extracted total RNA from these samples to investigate the global viral gene expression profiles and comparative genomic analysis of structural variations between the four different populations. Maximum likelihood phylogenic analysis indicated that OrNV strains from the Solomon Islands and the Philippines are closely related to while OrNV strains from PNG and Fiji formed a distinct adjacent clade. We detected several polymorphic sites with a frequency higher than 35% in 892 positions of the viral genome. The highest number of structural variants, including single nucleotide variants (SNV), insertion, deletion and non-synonymous mutations, were found in strains from Fiji and PNG when compared to complete recently sequenced Solomon Islands OrNV reference genome. Non-synonymous mutations were detected in several hypothetical proteins, and 15 nudivirus core genes such as OrNV_gp034 (DNA Helicase), lef-8, lef-4 and vp91 . For examination of the global gene expression profile of OrNV in chronically infected populations, we found limited evidence of variation between geographic populations. Only a few genes such as OrNV_gp01 (DNA polymerase B), OrNV_gp022 and OrNV_gp107 (Pif-3) were differentially expressed among different strains. Additionally, small RNA sequencing from the Solomon Islands population suggests that OrNV is targeted by the host RNA interference (RNAi) response with abundant 21nt small RNAs. Additionally, we identified a highly abundant putative 22 nt miRNA from the 3’ of a pre-miRNA-like hairpin originating from OrNV-gp-098 . These findings provide valuable resources for future studies to improve our understanding of the OrNV genetic variation. Some of these structural changes are specific to the geographic population and could be related to particular phenotypic characteristics of the strain, such as viral pathogenicity or transmissibility, and this requires further investigation." @default.
• W3030385140 created "2020-06-05" @default.
• W3030385140 creator A5004819642 @default.
• W3030385140 creator A5059931881 @default.
• W3030385140 creator A5074270720 @default.
• W3030385140 creator A5075963377 @default.
• W3030385140 date "2020-05-27" @default.
• W3030385140 modified "2023-10-16" @default.
• W3030385140 title "Genomic structural and transcriptional variation of Oryctes rhinoceros nudivirus (OrNV) in Coconut Rhinoceros Beetle" @default.
• W3030385140 cites W1571245828 @default.
• W3030385140 cites W1589531606 @default.
• W3030385140 cites W1977167384 @default.
• W3030385140 cites W1986127019 @default.
• W3030385140 cites W1986914206 @default.
• W3030385140 cites W1988093697 @default.
• W3030385140 cites W1995173041 @default.
• W3030385140 cites W1999739632 @default.
• W3030385140 cites W2015008321 @default.
• W3030385140 cites W2015593005 @default.
• W3030385140 cites W2019399051 @default.
• W3030385140 cites W2045021481 @default.
• W3030385140 cites W2051498559 @default.
• W3030385140 cites W2070641840 @default.
• W3030385140 cites W2078105351 @default.
• W3030385140 cites W2079769802 @default.
• W3030385140 cites W2089763683 @default.
• W3030385140 cites W2096103683 @default.
• W3030385140 cites W2100803850 @default.
• W3030385140 cites W2116816316 @default.
• W3030385140 cites W2121465721 @default.
• W3030385140 cites W2130305733 @default.
• W3030385140 cites W2130966777 @default.
• W3030385140 cites W2134499026 @default.
• W3030385140 cites W2159748410 @default.
• W3030385140 cites W2205909603 @default.
• W3030385140 cites W2223752691 @default.
• W3030385140 cites W2416464931 @default.
• W3030385140 cites W2516022550 @default.
• W3030385140 cites W2737482049 @default.
• W3030385140 cites W2745653121 @default.
• W3030385140 cites W2773195131 @default.
• W3030385140 cites W2810586525 @default.
• W3030385140 cites W2891114781 @default.
• W3030385140 cites W2896700798 @default.
• W3030385140 cites W2898440040 @default.
• W3030385140 cites W2900359059 @default.
• W3030385140 cites W2905792716 @default.
• W3030385140 cites W2952420811 @default.
• W3030385140 cites W2970392606 @default.
• W3030385140 cites W3000090711 @default.
• W3030385140 cites W3001044865 @default.
• W3030385140 cites W4211233159 @default.
• W3030385140 doi "https://doi.org/10.1101/2020.05.27.119867" @default.
• W3030385140 hasPublicationYear "2020" @default.
• W3030385140 type Work @default.
• W3030385140 sameAs 3030385140 @default.
• W3030385140 citedByCount "1" @default.
• W3030385140 countsByYear W30303851402020 @default.
• W3030385140 crossrefType "posted-content" @default.
• W3030385140 hasAuthorship W3030385140A5004819642 @default.
• W3030385140 hasAuthorship W3030385140A5059931881 @default.
• W3030385140 hasAuthorship W3030385140A5074270720 @default.
• W3030385140 hasAuthorship W3030385140A5075963377 @default.
• W3030385140 hasBestOaLocation W30303851401 @default.
• W3030385140 hasConcept C104317684 @default.
• W3030385140 hasConcept C141231307 @default.
• W3030385140 hasConcept C193252679 @default.
• W3030385140 hasConcept C24586158 @default.
• W3030385140 hasConcept C2777591057 @default.
• W3030385140 hasConcept C44465124 @default.
• W3030385140 hasConcept C54355233 @default.
• W3030385140 hasConcept C68873052 @default.
• W3030385140 hasConcept C78458016 @default.
• W3030385140 hasConcept C86803240 @default.
• W3030385140 hasConcept C90856448 @default.
• W3030385140 hasConceptScore W3030385140C104317684 @default.
• W3030385140 hasConceptScore W3030385140C141231307 @default.
• W3030385140 hasConceptScore W3030385140C193252679 @default.
• W3030385140 hasConceptScore W3030385140C24586158 @default.
• W3030385140 hasConceptScore W3030385140C2777591057 @default.
• W3030385140 hasConceptScore W3030385140C44465124 @default.
• W3030385140 hasConceptScore W3030385140C54355233 @default.
• W3030385140 hasConceptScore W3030385140C68873052 @default.
• W3030385140 hasConceptScore W3030385140C78458016 @default.
• W3030385140 hasConceptScore W3030385140C86803240 @default.
• W3030385140 hasConceptScore W3030385140C90856448 @default.
• W3030385140 hasLocation W30303851401 @default.
• W3030385140 hasOpenAccess W3030385140 @default.
• W3030385140 hasPrimaryLocation W30303851401 @default.
• W3030385140 hasRelatedWork W17263404 @default.
• W3030385140 hasRelatedWork W17824930 @default.
• W3030385140 hasRelatedWork W17857468 @default.
• W3030385140 hasRelatedWork W18785687 @default.
• W3030385140 hasRelatedWork W40067185 @default.
• W3030385140 hasRelatedWork W40360031 @default.
• W3030385140 hasRelatedWork W43492188 @default.
• W3030385140 hasRelatedWork W43756236 @default.
• W3030385140 hasRelatedWork W9316408 @default.
• W3030385140 hasRelatedWork W17583157 @default.
• W3030385140 isParatext "false" @default.

• next