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- W3030390507 abstract "目的 比较燃煤型砷中毒患者与正常人血细胞中基质金属蛋白酶-3(MMP-3)和基质金属蛋白酶抑制因子-3(TIMP-3)mRNA表达,分析MMP-3、TIMP-3基因在燃煤型砷中毒患者中的表达及其意义,阐明燃煤型砷中毒出现一系列临床症状的分子机制.方法分别采集燃煤型砷中毒患者与正常人外周血标本各50例,采用TRIzol-酚-氯仿一步法提取总RNA.紫外分光光度法测定RNA,波长(nm)260/280(A)鉴定RNA纯度.实时荧光定量PCR(RT-PCR)技术测定燃煤型砷中毒MMP-3、TIMP-3基因mRNA的表达,以β-肌动蛋白(β-actin)基因作为质控.结果燃煤型砷中毒患者血细胞中MMp-3 mRNA表达降低,为对照组的60%;TIMP-3mRNA表达升高,为对照组的140%,二者比较差异均有统计学意义(t=4.39,P＜0.01;t=2.46,P＜0.05).结论MMP-3、TIMP-3基因在燃煤型砷中毒代谢中发挥了重要的调控作用.MMP-3 mRNA表达降低和TIMP-3mRNA表达升高,可能是燃煤型砷中毒发病机制之一。" @default.
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- W3030390507 date "2005-03-20" @default.
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- W3030390507 title "Expression of MMP-3 and TIMP-3 gene in the patients suffered from coal-burning arsenism" @default.
- W3030390507 doi "https://doi.org/10.3760/cma.j.issn.1000-4955.2005.02.005" @default.
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