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- W3030394477 abstract "目的 通过电刺激清醒状态下猫上矢状窦区硬脑膜,制备反应可靠的偏头痛反复发作动物模型,探索偏头痛等血管源性头痛的发病机制.方法 体重为2~4 kg的短毛猫12只随机分为反复刺激组(n=4)、急性刺激组(n=4)、假手术对照组(n=4)三个组.反复刺激组每天刺激2 h,共刺激8 d;急性刺激组刺激1次,2 h;假手术对照组不予刺激.之后应用免疫组化技术,行延髓和上颈髓冰冻切片c-fos染色.结果 c-fos免疫反应阳性神经元主要位于延髓三叉神经脊束核尾侧部浅层和C1后角的Ⅰ、Ⅱ层.假手术对照组动物免疫反应阳性神经元较少,急性刺激组和反复刺激组免疫反应阳性神经元较假手术对照组显著增多(P<0.05),急性刺激组和反复刺激组免疫反应阳性神经元数无显著差异(P>0.05).结论 刺激上矢状窦区硬脑膜可激活在偏头痛痛觉中枢传递中起重要作用的三叉神经二级神经元。" @default.
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- W3030394477 date "2007-09-15" @default.
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- W3030394477 title "Impact on the excitability of second-order neurons of the trigeminal nerve by iterative electrical stimulation of the dura mater near the SSS in conscious cats" @default.
- W3030394477 doi "https://doi.org/10.3760/cma.j.issn.1671-8925.2007.09.015" @default.
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