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- W3030401889 abstract "A number of studies showed adverse intrauterine environment , especially inadequate or excessive intake of nutrients in pregnancy are likely to affect the normal development of fetus , change the genes phenotype associated with fetal energy metabolism through the interaction with fetal genetic factors , and lead to increased risks of developing obesity , insulin resistance and type 2 diabetes in adult hood . Studies also indicated that eip-genetic factors such as DNA methylation , histone modification and the miR-NA expression would have far-reaching impacts on fetal development , energy metabolism and type 2 diabe-tes .This review summarized recent literatures about the impacts of nutritional imbalance during pregnancy on the development of type Ⅱ diabetes .Expect to provide scientific advices for maternal dietary intake and prevention of type 2 diabetes .Key words: Pregnancy; Nutrition; Fetal development; Type 2 diabetes mellitus; Epige-netics" @default.
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- W3030401889 date "2014-12-15" @default.
- W3030401889 modified "2023-09-25" @default.
- W3030401889 title "Advances in the studies of epigenetic mechanisms linking pregnancy nutrition imbalances with off-spring type 2 diabetes risk" @default.
- W3030401889 doi "https://doi.org/10.3760/cma.j.issn.1673-4386.2014.06.007" @default.
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