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- W3030407974 abstract "ObjectiveTo investigate the correlation between serum vitamin D level in human body and Chlamydia trachomatis (Ct) genitourinary tract infection.MethodsThis study enrolled 174 outpatients (male: 95, female: 79, 20-49 years) infected with Ct and 380 healthy subjects (male: 211, female: 169, 20-49 years) in Tianjin from November 1, 2016 to March 15, 2017. Blood samples were collected from all subjects after fasting overnight and the time points for sample collection in the Ct infection group were before and after a course of antibiotic treatment. Serum 25-hydroxyvitamin D [25-(OH)D] levels were measured with enzyme-linked immunosorbent assay (ELISA). PCR assay was used to assess the recovery in those patients one month after a course of treatment. Two case-control studies were respectively conducted, in which 161 patients and 161 healthy subjects as well as 41 uncured patients and 41 cured patients were randomly selected and matched for gender and age. Statistical analysis was performed using SPSS19.0.ResultsThe two case-control studies showed that vitamin D deficiency was a risk factor for both Ct genital tract infection and poor efficacy, of which the adjusted ORs were 2.281 (95% CI: 1.438, 3.619) and 7.266 (95% CI: 2.551, 21.036). Among all subjects aged 20-39, male patients had lower 25-(OH)D level in serum than healthy men [(40.10±17.93) nmol/L vs (53.72±18.00) nmol/L, P< 0.01] and female patients also had lower 25-(OH)D level in serum than healthy women [(35.71±19.99) nmol/L vs (45.42±16.08) nmol/L, P<0.01]. The levels of 25-(OH)D in uncured male and female patients were respectively lower than those in cured male and female patients [(30.50±14.53) nmol/L vs (41.32±17.24) nmol/L; (29.47±16.66) nmol/L vs (41.37±21.03) nmol/L; both P<0.05].ConclusionVitamin D deficiency related to Ct infection in human genitourinary tract and poor prognosis. Lower serum vitamin D levels might increase the risk of Ct genitourinary tract infection and reduce the efficacy of treatment.Key words: Chlamydia trachomatis; Genitourinary tract infection; Vitamin D; 25-hydroxyvitamin D" @default.
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- W3030407974 date "2018-10-31" @default.
- W3030407974 modified "2023-09-27" @default.
- W3030407974 title "Preliminary correlation analysis between human serum vitamin D level and Chlamydia trachomatis genitourinary tract infection" @default.
- W3030407974 doi "https://doi.org/10.3760/cma.j.issn.0254-5101.2018.10.008" @default.
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