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- W3030408071 abstract "Objective The purpose of this investigation was to investigate the neuroprotective effects of rhubarb for ICH,as well as its mechanism.Methods ICH was produced in adult Spargue-Dawley rats by injection of collagenase IV(0.05U/0.5uL).Intraperitoneal injection of rhubarb (70mg/kg) or saline,was started at 3,6 or 12 hours post-ICH respectivdy.Casepase-3 activity.TUNEL and neurological behavior function were performed 24hours after ICH.Results Rhubarb siven at 3 or 6 hours can inhibit casepase-3 activity(P<0.001),reduce TUNEL positive cells(P<0.05) and attenuate apomorphine-induced rotation(P<0.05) at 24 hours after ICH.However,the animals which were treated 12 hours showed no improvement.Conclusion Rhubarb may be a potential drug for ICH patients for its possible effect of inhibiting apoptosis.Key words: Intraccrebral hemorrhage; Rhubarb; Apoptosis" @default.
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- W3030408071 date "2010-01-01" @default.
- W3030408071 modified "2023-09-23" @default.
- W3030408071 title "Effect of Rhubarb on Neurological Injury and Apoptosis in ICH rats" @default.
- W3030408071 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2010.01.012" @default.
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