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- W3030426758 abstract "ObjectiveTo analyze plasma level of catestatin and its clinical significance in patients with different types of atrial fibrillation.MethodsA total of 84 consecutive patients with atrial fibrillation were enrolled in this study. Atrial fibrillation was categorized as paroxysmal atrial fibrillation(n=61) and chronic atrial fibrillation (n=23). Another 46 patients matched for concomitant diseases in sinus rhythm without any atrial fibrillation history consisted of control group. Medical history, physical examination, laboratory parameters and echocardiography were recorded. Plasma levels of catestatin were measured by ELISA and compared between groups.ResultsPlasma catestatin levels were decreased in overall atrial fibrillation group than in control group [0.54(0.34-0.96) mg/L vs.0.87(0.59-1.31) mg/L, Z=-3.491, P 125 ng/L) (OR=12.416, P<0.001)were the independent predictors of atrial fibrillation. Using a receiver operating characteristic curve, the optimal cut-off value for plasma CST was 0.73 mg/L in the diagnosis of paroxysmal atrial fibrillation with 60.9% sensitivity and 63.9% specificity, the area under the curve(AUC) was 0.659 (P=0.005).ConclusionsPlasma catestatin levels of patients with atrial fibrillation are significantly decreased. Lower catestatin level may be the independent factor associated with atrial fibrillation incidence.Key words: Atrial fibrillation; Catestatin" @default.
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- W3030426758 date "2015-04-25" @default.
- W3030426758 modified "2023-09-24" @default.
- W3030426758 title "Plasma level of catestatin in patients with different types of atrial fibrillation" @default.
- W3030426758 doi "https://doi.org/10.3969/j.issn.1007-5410.2015.02.002" @default.
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