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- W3030427981 abstract "The body plan along the anteroposterior axis and regional identities are specified by the spatiotemporal expression of Hox genes. Multistep controls are required for their unique expression patterns; however, the molecular mechanisms behind the tight control of Hox genes are not fully understood. In this study, we demonstrated that the Lin28a/let-7 pathway is critical for axial elongation. Lin28a–/– mice exhibited axial shortening with mild skeletal transformations of vertebrae, which were consistent with results in mice with tail bud-specific mutants of Lin28a. The accumulation of let-7 in Lin28a–/– mice resulted in the reduction of PRC1 occupancy at the Hox cluster loci by targeting Cbx2. Consistently, Lin28a loss in embryonic stem-like cells led to aberrant induction of posterior Hox genes, which was rescued by the knockdown of let-7. These results suggest that the Lin28/let-7 pathway is involved in the modulation of the ‘Hox code’ via Polycomb regulation during axial patterning." @default.
- W3030427981 created "2020-06-05" @default.
- W3030427981 creator A5013103326 @default.
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- W3030427981 date "2020-05-29" @default.
- W3030427981 modified "2023-09-27" @default.
- W3030427981 title "Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates" @default.
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