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- W3030431736 abstract "Objective To evaluate the clinical value of 18F-fluoroethylcholine (FECH) PET/CT imaging in the diagnosis of prostate cancer and to investigate its physiological or non-cancerous uptake.Methods The subjects consisted of 30 patients(age ranged from 56 to 83 years,mean age 61 years)with pathologically confirmed prostate cancer,in whom 18F-FECH and 18F-FDG PET/CT scans were undertaken from October 2009 to December 2011.The sensitivity and accuracy of the two tracers in detecting prostate cancer were compared.SUV was obtained for quantitative analysis.x2 test and t test were used for statistic analysis.Results Of the 30 patients,41 lesions presented high uptake in prostate region.The sensitivity and accuracy for diagnosing prostate cancer with 18F-FECH PET/CT were 87.9％ (29/33) and 82.9％(34/41),respectively,while the sensitivity and accuracy with 18F-FDG PET/CT were 36.4％ (12/33) and 36.6％ (15/41),respectively.There were significant differences in sensitivity and accuracy between the two methods (x2 =8.1 and 11.1,both P ＜ 0.05).Physiological uptake appeared in the liver,pancreas,spleen,salivary gland,and also,owing to renal excretion,in the urinary tract.The SUVmax in liver and pancreas were 10.1 ± 1.6 and 6.1 ± 1.1,respectively.The SUV was 6.0 ± 2.2 in prostate cancer,while it was 2.6 ± 1.3 in benign lesions (t =2.9,P ＜ 0.05).Other abnormalities that were not related to prostate cancer were detected in 10 patients.Of these 10 patients,there were 6 with inflammation,1 with lymphoma,1 with tuberculosis,1 with lung cancer and 1 with germinoma in pineal body.Conclusions 18 F-FECH PET/CT is promising for diagnosis of prostate cancer.Understanding the biodistribution and pitfalls of 18F-FECH is very important for image interpretation.Key words: Prostatic neoplasms; Tomography,emisson-computed; Tomography,X-ray computed; Choline" @default.
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- W3030431736 date "2012-10-25" @default.
- W3030431736 modified "2023-10-12" @default.
- W3030431736 title "The clinical value and pitfalls of 18F-fluoroethylcholine PET/CT imaging in the diagnosis of prostate cancer" @default.
- W3030431736 doi "https://doi.org/10.3760/cma.j.issn.2095-2848.2012.05.009" @default.
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