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- W3030432080 abstract "ObjectiveTo investigate the expression of miRNA (miR-21) in mucosa-associated lymphoid tissue(MALT) lymphomas and its relationship with the effects in CHOP regimen.MethodsLymph gland tissues and preoperative peripheral blood of 52 patients pathologically diagnosed with MALT lymphoma in Department of Hematology of Affiliated Hospital of Hebei University of Engineering from January 2015 to December 2017 were collected; meanwhile, 10 tissues from patients with lymphadenitis and 20 peripheral serum from healthy examination patients were also collected. Quantitative real-time polymerase chain reaction (qPCR) was used to compare the lymph gland tissues in MALT lymphoma patients and lymphadenitis patients, and the expression of miR-21 in peripheral serum of MALT lymphoma and healthy people. The selected 20 cases of MALT lymphoma were given CHOP regimen treatment for 6 cycles, and then the efficiency and inefficiency were compared; at the same time, the expression of miR-21 in peripheral serum of the patients in the effective group was detected.ResultsThe relative expression of miR-21 of lymph node tissues in lymphadenitis patients and MALT lymphoma patients was 1.03±0.12 and 4.53±0.73 respectively, and the relative expression of miR-21 in preoperative peripheral serum of healthy people and MALT lymphoma patients was 0.83±0.04 and 3.87±0.21 respectively, and the differences were statistically significant (P= 0.047, P= 0.044). After 6 cycles of CHOP regimen, the total effect rate of MALT lymphoma was 70% (14/20), and the relative expression of miR-21 in preoperative and postoperative peripheral serum for the patients who obtained the effective results after CHOP regimen was 3.95±0.08 and 1.62±0.41, and the differences were statistically significant (P= 0.035).ConclusionsThe expression of miR-21 has a certain correlation with the occurrence and development of MALT lymphoma. Furthermore, the serum miR-21 expression may be related to the effect of CHOP regimen chemotherapy in MALT lymphoma.Key words: Mucosa associated-lymphoid tissue lymphoma; miRNA-21; CHOP regimen; Treatment outcome" @default.
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- W3030432080 date "2018-12-25" @default.
- W3030432080 modified "2023-09-26" @default.
- W3030432080 title "Expression of miRNA-21 in mucosa-associated lymphoid tissue lymphomas and its relationship with CHOP regimen" @default.
- W3030432080 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2018.12.009" @default.
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