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- W3030444575 abstract "ObjectiveTo explore the characteristics of chromosome karyotypes in patients with chronic myeloid leukemia (CML), and to provide help to individualized treatment.MethodsThe date of chromosome karyotypes of 313 patients and FISH of 45 of these patients with CML excluding Ph chromosome negative (Ph-) after treatment were collected from January 2014 to June 2015. Karyotypes were detected by R-banding.ResultsIn the 313 cases, 307 cases (98.08 %) were Ph chromosome positive (Ph+) and 6 cases (1.92 %) were Ph-. In the Ph+ patients, 288 cases (93.81 %) were classical Ph+, and 19 cases (6.19 %) were variant rearrangements. There were 48 cases (15.34 %) with additional chromosome changes in all patients, including 41 cases (13.10 %) with classical Ph+ and 7 cases (2.24 %) with variant rearrangements. The most common additional chromosome changes were in the following order: + der(22) Ph (35.42 %), + 8 (33.33 %) and + 21 (12.50 %). The most frequent pattern of combination was +der(22) combined with +8 (16.67 %) , followed by +8 combined with + 21 (10.42 %). The proportion of pure Ph+ patients in chronic phase was higher than that of advanced phase, but proportion of classical Ph+ patients with additional chromosome changes in chronic phase was lower than that in advanced phase (χ2 = 111.55, P < 0.01). The proportions of chronic phase and advanced phase patients with simple variant rearrangements were not different from those with complex variant rearrangements (P= 0.582). The results of FISH in 45 cases were all positive, including 5 cases with 2 G1R1Y.ConclusionKaryotype analysis can reveal the instability of genetic and the characteristics of disease progression by identifying the evolution of Ph, which provides the basis for clinical doctors to choose suitable treatment.Key words: Leukemia, myeloid, chronic; Analysis of chromosome karyotyping; Fluorescence in situ hybridization; Variant translocation; Additional chromosome abnormalities" @default.
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- W3030444575 date "2016-04-25" @default.
- W3030444575 modified "2023-09-25" @default.
- W3030444575 title "Analysis of chromosome karyotype characteristics in patients with chronic myeloid leukemia" @default.
- W3030444575 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2016.04.007" @default.
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