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• W3030447672 abstract "Objective To investigate the correlation between lymphotactin(Ltn)and pulmonary candidiasis albicans in rats.Methods Eighty male SD rats(150-180 g,30-40 days of age)were randomly divided into control group and model group(n = 40).In model group,pulmonary candidiasis albicans model was prepared by the injection of Candida albicans from the trachea.Experimental animals were sacrificed at 1 d,3 d,7 d,11 d after vaccination,and ventricle blood was taken.The levels of Ltn,interferon-γ(IFN-γ),interleukin-2(IL-2)in serum were measured by double-antibody sandwich ABC-enzyme linked immunosorbent assay.Lung tissues were taken for tissue pathology examination and pathogen count training.The data were analyzed by SPSS 13.0.Results Inflammatory reaction was observed in model 1 d,3 d,7 d,11 d groups.Szapiel scores were 1.70 ±0.48,3.60±0.70,2.90±0.57,1.30± 0.52,respectively.The numbers of bacterial load were(3.50±1.07)× 106 cfu/ml,(4.60± 1.08)× 106 cfu/ml,(1.30± 0.48)× 106 cfu/ml,(0.10± 0.32)× 106 cfu/ml,respectively.Compared with control group,the levels of Ltn,IFN-γ and IL-2 increased in model 1 d,3 d,7 d,11 d groups(P <0.05).There was positive correlation between Ltn level and the degree of inflammation,the number of coenobium,the levels of IFN-γ and IL-2 in model group(r = 0.816,0.647,0.846,0.823,all P <0.05).Conclusions Ltn might participate in the course of fungal infection,and play a positively synergistical role with IFN-γ,IL-2 on the elimination of pathogens.Objective To investigate the correlation between lymphotactin(Ltn)and pulmonary candidiasis albicans in rats.Methods Eighty male SD rats(150-180 g,30-40 days of age)were randomly divided into control group and model group(n = 40).In model group,pulmonary candidiasis albicans model was prepared by the injection of Candida albicans from the trachea.Experimental animals were sacrificed at 1 d,3 d,7 d,11 d after vaccination,and ventricle blood was taken.The levels of Ltn,interferon-γ(IFN-γ),interleukin-2(IL-2)in serum were measured by double-antibody sandwich ABC-enzyme linked immunosorbent assay.Lung tissues were taken for tissue pathology examination and pathogen count training.The data were analyzed by SPSS 13.0.Results Inflammatory reaction was observed in model 1 d,3 d,7 d,11 d groups.Szapiel scores were 1.70 ±0.48,3.60±0.70,2.90±0.57,1.30± 0.52,respectively.The numbers of bacterial load were(3.50±1.07)× 106 cfu/ml,(4.60± 1.08)× 106 cfu/ml,(1.30± 0.48)× 106 cfu/ml,(0.10± 0.32)× 106 cfu/ml,respectively.Compared with control group,the levels of Ltn,IFN-γ and IL-2 increased in model 1 d,3 d,7 d,11 d groups(P <0.05).There was positive correlation between Ltn level and the degree of inflammation,the number of coenobium,the levels of IFN-γ and IL-2 in model group(r = 0.816,0.647,0.846,0.823,all P <0.05).Conclusions Ltn might participate in the course of fungal infection,and play a positively synergistical role with IFN-γ,IL-2 on the elimination of pathogens.Key words: Candida albicans; Pneumonia; Lymphotactin" @default.
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• W3030447672 date "2010-04-20" @default.
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• W3030447672 title "Research of correlation between lymphotactin and pulmonary candidiasis albicans in rats" @default.
• W3030447672 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2010.08.003" @default.
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